Tomita Masaki, Ayabe Takanori, Nakamura Kunihide
Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kihara 5200, Kiyotake, Miyazaki, Japan. Email:
Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3353-3356. doi: 10.22034/APJCP.2017.18.12.3353.
Background: The effect of body mass index (BMI) on postoperative survival in non-small cell lung cancer (NSCLC) has been controversial. We retrospectively analysed the effect of preoperative BMI on postoperative outcomes of NSCLC surgery. Methods: Consecutive 384 NSCLC patients were enrolled. Patients were subdivided into 3 groups: low BMI group (BMI<18.5 kg/m2), normal BMI group (BMI=18.5-24.0 kg/m2) and high BMI group (BMI>24.0 kg/m2). The prognostic significance of BMI was examined retrospectively. Results: The 5-year survival of patients with low, normal and high BMI groups were 46.3%, 74.3% and 84.3%, respectively. The low BMI group had a poorer prognosis than the other groups (p<0.001). The survival of high BMI group had a more favorable trend than that of normal BMI group, but this did not reach statistical significance (p=0.057). On multivariate analysis, significant risk factors for cancer-specific survival were male gender (p=0.0061), non-adenocarcinoma histology (p=0.0003), pN1-2 status (p=0.0007), high serum CEA level (p<0.0001) and low BMI (low vs. others: p <0.0001). Conclusions: Preoperative BMI is an independent prognostic factor for NSCLC patients after surgical resection, with low BMI patients having an unfavorable prognosis.
体重指数（BMI）对非小细胞肺癌（NSCLC）术后生存的影响一直存在争议。我们回顾性分析了术前BMI对NSCLC手术患者术后结局的影响。方法：纳入384例连续的NSCLC患者。患者被分为3组：低BMI组（BMI<18.5 kg/m²）、正常BMI组（BMI=18.5-24.0 kg/m²）和高BMI组（BMI>24.0 kg/m²）。回顾性研究BMI的预后意义。结果：低、正常和高BMI组患者的5年生存率分别为46.3%、74.3%和84.3%。低BMI组的预后比其他组差（p<0.001）。高BMI组的生存率比正常BMI组有更有利的趋势，但未达到统计学意义（p=0.057）。多因素分析显示，癌症特异性生存的显著危险因素为男性（p=0.0061）、非腺癌组织学类型（p=0.0003）、pN1-2状态（p=0.0007）、高血清癌胚抗原水平（p<0.0001）和低BMI（低BMI组与其他组比较：p<0.0001）。结论：术前BMI是NSCLC患者手术切除后的独立预后因素，低BMI患者预后不良。
