González María Magdalena, Altermatt Fernando
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Proyecto Epistemonikos, Santiago, Chile; Departamento de Anestesiología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email:
Medwave. 2017 Dec 29;17(9):e7121. doi: 10.5867/medwave.2017.09.7121.
Lidocaine is widely used in anesthesia due to its multiple properties, including its role as analgesic. However, it is not entirely clear which are the real benefits of its use in the perioperative setting.
To answer this question we used Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.
We identified 15 systematic reviews including 53 studies overall, all of them randomized controlled trials. We concluded the use of intravenous perioperative lidocaine probably results in a clinically irrelevant difference in pain and length of hospital stay, but it probably prevents postoperative nausea and vomiting.
利多卡因因其多种特性，包括其镇痛作用，而被广泛应用于麻醉领域。然而，在围手术期使用利多卡因的真正益处尚不完全明确。
为回答这个问题，我们使用了Epistemonikos，这是最大的健康领域系统评价数据库，通过筛选包括MEDLINE、EMBASE、Cochrane等在内的多个信息来源进行维护。我们从系统评价中提取数据，重新分析原始研究的数据，进行荟萃分析，并使用GRADE方法生成结果总结表。
我们识别出15项系统评价，总共包括53项研究，所有这些研究均为随机对照试验。我们得出结论，围手术期静脉注射利多卡因可能在疼痛和住院时间方面产生临床上无显著意义的差异，但可能预防术后恶心和呕吐。
