Stuardo Camila, Lobos-Urbina Diego, Altermatt Fernando
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile. Email:
Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, Chile.
Medwave. 2017 May 17;17(Suppl2):e6952. doi: 10.5867/medwave.2017.6952.
Ketamine is a N-Metil-D-Aspartate receptor antagonist that has been used as adjuvant in the acute postoperative pain management because of its analgesic properties. However, its role is not clearly determined. To answer this question, we searched in Epistemonikos database, which is maintained by screening multiple information sources. We identified 19 systematic reviews including 226 randomized trials overall. We extracted data and generated a summary of findings table using the GRADE approach. We concluded intravenous ketamine probably has little or no effect in reducing postoperative pain.
氯胺酮是一种N-甲基-D-天冬氨酸受体拮抗剂，因其镇痛特性而被用作急性术后疼痛管理的辅助药物。然而，其作用尚未明确确定。为了回答这个问题，我们在由多个信息来源筛选维护的Epistemonikos数据库中进行了检索。我们确定了19项系统评价，总共包括226项随机试验。我们提取了数据，并使用GRADE方法生成了结果总结表。我们得出结论，静脉注射氯胺酮在减轻术后疼痛方面可能几乎没有效果或根本没有效果。
