Duan Lian, Hu Junyuan, Xiong Xingjiang, Liu Yongmei, Wang Jie
Department of Cardiology, Guang' An men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China; Graduate School, Beijing University of Traditional Chinese Medicine, No.11 North Third Ring Road, Chaoyang District, Beijing, China.
Department of Cardiology, Guang' An men Hospital, China Academy of Chinese Medical Science, No.5 Bei xiange, Xicheng District, Beijing, China.
Gene. 2018 Mar 10;646:91-97. doi: 10.1016/j.gene.2017.12.033. Epub 2017 Dec 27.
Epigenetic studies have identified DNA methylation in coronary artery disease (CAD). How the critical genes interact at the cellular level to cause CAD is still unknown. The discovery of DNA methylation inspired researchers to explore relationships in genomic coding and disease phenotype. In the past two decades, there have been many findings regarding the relationship between DNA methylation and CAD development, and the DNA methylation of critical genes have been found to be significantly changed during CAD, including DNA methylation at homocysteine, Alu and long Interspersed Element 1 (LINE-1) repetitive elements. Here, we provide a brief overview of the biology and mechanisms of DNA methylation and its roles in CAD. We also discuss recent findings regarding DNA methylation of homocysteine, Alu and LINE-1 and some genes on CAD in vitro and in vivo. Finally, we provide some perspectives on DNA methylation in CAD.
表观遗传学研究已确定冠状动脉疾病（CAD）中存在DNA甲基化现象。关键基因在细胞水平上如何相互作用导致CAD仍不清楚。DNA甲基化的发现促使研究人员探索基因组编码与疾病表型之间的关系。在过去二十年中，已有许多关于DNA甲基化与CAD发生之间关系的研究发现，并且已发现关键基因的DNA甲基化在CAD期间发生了显著变化，包括同型半胱氨酸、Alu和长散在核元件1（LINE-1）重复元件处的DNA甲基化。在此，我们简要概述DNA甲基化的生物学特性和机制及其在CAD中的作用。我们还讨论了关于同型半胱氨酸、Alu和LINE-1以及一些基因在体外和体内对CAD的DNA甲基化的最新研究发现。最后，我们对CAD中的DNA甲基化提供了一些观点。
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