Arakawa Hiroyuki
Rodent Behavioral Core, Department of Research Administration, Case Western Reserve University School of Medicine, 2109 Adelbert Rd., ARC-RB05P, Cleveland, OH, 44106, USA.
Behav Brain Res. 2018 Apr 2;341:98-108. doi: 10.1016/j.bbr.2017.12.022. Epub 2017 Dec 26.
The aim of the present review is to discuss how housing conditions affect behavioral performance in laboratory rodents from an ethological view. Commonly used laboratory rodents such as rats and mice, are originally captured animals that largely retain species-typical natural behaviors, while have fully adapted to a laboratory setting after long-term domestication. Laboratory settings including caging and artificial group housing are a considerable ethological factor influencing rodents' behaviors in commonly employed behavioral test paradigms, including emotional and defensive behaviors, learning and memory, and attention-related behaviors. Particularly, isolation rearing, single-housed in a cage, is referred to a deprivation of social relationships with cagemates, has a substantial impact on behavioral performance in laboratory rodents. In this review, we will fully examine the importance of caging related ethological factors, e.g., social relationships and its deprivation, which are essential for unraveling the nature of housing effect in laboratory rodents. These discussions regarding the housing conditions will provide valuable information for appropriately conducting behavioral studies and interpreting data of rodents' behaviors in neuroscience.
本综述的目的是从行为学角度探讨饲养条件如何影响实验啮齿动物的行为表现。常用的实验啮齿动物，如大鼠和小鼠，原本是捕获的动物，在很大程度上保留了物种典型的自然行为，同时经过长期驯化后已完全适应了实验室环境。包括笼养和人工群居在内的实验室环境是影响啮齿动物在常用行为测试范式中行为的一个重要行为学因素，这些范式包括情绪和防御行为、学习和记忆以及注意力相关行为。特别是，隔离饲养，即单独饲养在笼子里，被认为是剥夺了与同笼伙伴的社会关系，对实验啮齿动物的行为表现有重大影响。在本综述中，我们将全面研究与笼养相关的行为学因素的重要性，例如社会关系及其剥夺，这对于阐明实验啮齿动物饲养效应的本质至关重要。这些关于饲养条件的讨论将为在神经科学中适当地进行行为研究和解释啮齿动物行为数据提供有价值的信息。
