Centre de recherche Epidémiologie, Biostatistiques, Recherche Clinique, School of Public Health, Université Libre de Bruxelles (U.L.B.), Route de Lennik 808, CP 596, 1070 Brussels, Belgium.
Agence pour une Vie de Qualité, Rue de la Rivelaine 21, 6061 Charleroi, Belgium.
Int J Cardiol. 2018 Mar 15;255:231-236. doi: 10.1016/j.ijcard.2017.12.058. Epub 2017 Dec 24.
Many studies have shown a short-term association between NO and cardiovascular disease. However, few data are available on the delay between exposure and a health-related event. The aim of the present study is to determine the strength of association between NO and cardiovascular health in Wallonia for the period 2008-2011. This study also seeks to evaluate the effects of age, gender, season and temperature on this association. The effect of the delay between exposure and health-related event was also investigated. The daily numbers of hospital admissions for arrhythmia, acute myocardial infarction, ischemic and haemorrhagic stroke were taken from a register kept by Belgian hospitals. Analyses were performed using the quasi-Poisson regression model adjusted for seasonality, long-term trend, day of the week, and temperature. Our study confirms the existence of an association between NO and cardiovascular disease. Apart from haemorrhagic stroke, the strongest association between NO concentrations and number of hospital admissions is observed at lag 0. For haemorrhagic stroke, the association is strongest with a delay of 2days. All associations calculated without stratification are statistically significant and range from an excess relative risk of 2.8% for myocardial infarction to 4.9% for haemorrhagic strokes. The results of this study reinforce the evidence of the short-term effects of NO on hospital admissions for cardiovascular disease. The different delay between exposure and health-related event for haemorrhagic stroke compared to ischemic stroke suggests different mechanisms of action.
许多研究表明，NO 与心血管疾病之间存在短期关联。然而，关于暴露与健康相关事件之间的延迟时间，可用的数据很少。本研究旨在确定 2008-2011 年期间，NO 与瓦隆大区心血管健康之间的关联强度。本研究还试图评估年龄、性别、季节和温度对这种关联的影响。还研究了暴露与健康相关事件之间的延迟时间的影响。心律失常、急性心肌梗死、缺血性和出血性中风的每日住院人数从比利时医院保存的登记处获取。使用经过季节性、长期趋势、星期几和温度调整的拟泊松回归模型进行分析。我们的研究证实了 NO 与心血管疾病之间存在关联。除出血性中风外，NO 浓度与住院人数之间的最强关联出现在滞后 0 天。对于出血性中风，与 2 天的延迟时间关联最强。所有未分层计算的关联均具有统计学意义，范围从心肌梗死的超额相对风险 2.8%到出血性中风的 4.9%。本研究的结果增强了 NO 对心血管疾病住院人数的短期影响的证据。暴露与出血性中风相关的健康相关事件之间的延迟时间与缺血性中风不同，这表明作用机制不同。
