Health Services and Outcomes Research, National Healthcare Group, Singapore.
Ann Acad Med Singap. 2017 Nov;46(11):417-423.
The risk of lower extremity amputations (LEAs) in diabetics is 20 times higher than in non-diabetics. Clinical practice guidelines recommend that all diabetics should receive an annual foot examination to identify high-risk foot conditions. Despite this recommendation, there is little evidence in the literature to show its effectiveness in preventing LEA. This study aims to evaluate the effectiveness of diabetes foot screening in primary care in preventing LEA and to identify LEA risk factors.
This is a retrospective cohort study of diabetic patients who visited the National Healthcare Group Polyclinics for the first time from 1 January 2008 to 31 December 2012. The intervention of interest was foot screening performed at least once during 2 years of follow-up, and the outcome of interest was LEA (major and/or minor) performed during 2 years of follow-up. Patients who did foot screening (n=8150) were compared to a propensity score matched control group (n=8150) who did not do foot screening. Logistics regression was done to identify factors associated with LEA.
Among those who underwent foot screening, there were 2 (0.02%) major amputations and 15 (0.18%) minor amputations compared with 42 (0.52%) and 52 (0.64%) among those who did not (<0.001).
Lack of diabetes foot screening, lower socioeconomic status, hip fracture, Malay ethnicity, chronic kidney disease, poorer glycaemic control, longer diabetes duration and male gender have been found to be associated with a higher risk of LEA.
糖尿病患者下肢截肢(LEA)的风险是非糖尿病患者的 20 倍。临床实践指南建议所有糖尿病患者每年都应进行足部检查,以确定高危足部状况。尽管有此建议,但文献中几乎没有证据表明其在预防 LEA 方面的有效性。本研究旨在评估初级保健中糖尿病足筛查预防 LEA 的效果,并确定 LEA 的危险因素。
这是一项回顾性队列研究,纳入了 2008 年 1 月 1 日至 2012 年 12 月 31 日期间首次到新加坡国立医疗集团综合诊疗所就诊的糖尿病患者。感兴趣的干预措施是在 2 年随访期间至少进行一次足部筛查,感兴趣的结局是在 2 年随访期间进行的 LEA(主要和/或次要)。将接受足部筛查的患者(n=8150)与未接受足部筛查的倾向评分匹配对照组(n=8150)进行比较。使用逻辑回归来确定与 LEA 相关的因素。
在接受足部筛查的患者中,有 2 例(0.02%)发生了主要截肢,15 例(0.18%)发生了次要截肢,而未接受足部筛查的患者中,有 42 例(0.52%)和 52 例(0.64%)发生了主要和次要截肢(<0.001)。
未进行糖尿病足筛查、社会经济地位较低、髋部骨折、马来族裔、慢性肾脏病、血糖控制较差、糖尿病病程较长和男性,这些因素与 LEA 风险增加相关。