Ehab Ahmed, Khairy El-Badrawy Mohammad, Abdelhamed Moawad Amr, El-Dosouky Abo-Shehata Mohammad
chest medicine department, faculty of medicine, mansoura university, Elgmoheria street, 35151 Mansoura, Egypt.
Adv Respir Med. 2017;85(6):301-306. doi: 10.5603/ARM.2017.0052.
This study aimed to evaluate the safety and diagnostic yield of CB in comparison to forceps biopsy in endobronchial lesions.
Patients with suspected endobronchial lesions were enrolled. Two forceps biopsies and one cryobiopsy were done in the same patient with randomized sequence. The largest diameter of the samples was measured in mm by electronic caliper. Diagnostic yield of each technique and postbronchoscopy bleeding were evaluated.
Samples obtained by CB was significantly larger than that of the forceps biopsy (5.9 ± 2.3 vs 2.5 ± 0.8), (p = 0.001). Diagnostic yield of CB was significantly higher than forceps biopsy 74.5% versus 51.1% (p = 0.001). Mild and moderate bleeding grades were reported in both techniques with no significant difference (p = 0.063) (p = 0.5) respectively. Severe bleeding was not recorded in both techniques.
CB represents a safe and effective tool to obtain a larger tissue samples of a good quality with higher diagnostic yield in comparison to standard forceps samples. On the other hand, bleeding occurred more frequently after CB than forceps biopsy. However, without severe adverse effects.
本研究旨在评估与钳取活检相比，冷冻活检在支气管内病变中的安全性和诊断率。
纳入疑似支气管内病变的患者。对同一患者按随机顺序进行两次钳取活检和一次冷冻活检。用电子卡尺以毫米为单位测量样本的最大直径。评估每种技术的诊断率和支气管镜检查后出血情况。
冷冻活检获得的样本明显大于钳取活检（5.9±2.3对2.5±0.8），（p = 0.001）。冷冻活检的诊断率明显高于钳取活检，分别为74.5%对51.1%（p = 0.001）。两种技术均报告有轻度和中度出血分级，无显著差异（分别为p = 0.063）（p = 0.5）。两种技术均未记录到严重出血。
与标准钳取样本相比，冷冻活检是一种安全有效的工具，可获取更大质量更好的组织样本，诊断率更高。另一方面，冷冻活检后出血比钳取活检更频繁。然而，无严重不良反应。
