Dragomir Mihnea, Eftimie Mihai Adrian
Chirurgia (Bucur). 2017 Nov-Dec;112(6):653-663. doi: 10.21614/chirurgia.112.6.653.
RAMPS is considered, in high volume centers, as the best treatment for adenocarcinoma of the body and tail of the pancreas. PubMed database was searched. The results of studies that compared RAMPS with SRPS were analyzed by meta-analytical methods. Five studies, published between 2013 and 2016, were suitable for quantitative synthesis. 285 unique patients were included, 135 patients in the RAMPS group and 150 patients in the SRPS group. Regarding retrieved lymph nodes, the mean difference was 6.54. This difference was considered to be statistical significant, P 0.00001. A complete tumor resection was observed in 115 of 129 patients who underwent RAMPS and in the case of the standard procedure a R0 resection was obtained in 107 cases out of 137, the RR was 1.17 (95% CI, 1.04, 1.32). One-year overall survival was found to be 79.2% in the RAMPS groups compared with 64.29% in the SRPS group. This difference is considered statistically significant, with a P value of 0.02. RAMPS is a safe procedure for the treatment of adenocarcinomas of the body and tail of the pancreas. RAMPS procedure is superior to SRPS in terms of lymph node retrieval and R0 resections.
在高容量中心，逆行胰体尾切除术（RAMPS）被认为是治疗胰体尾腺癌的最佳方法。检索了PubMed数据库。采用荟萃分析方法分析了比较RAMPS与标准逆行胰体尾切除术（SRPS）的研究结果。2013年至2016年间发表的五项研究适合进行定量综合分析。纳入了285例独特患者，其中RAMPS组135例，SRPS组150例。关于获取的淋巴结，平均差异为6.54。该差异被认为具有统计学意义，P<0.00001。在接受RAMPS的129例患者中，有115例实现了肿瘤完全切除；在标准手术组中，137例中有107例实现了R0切除，相对危险度（RR）为1.17（95%可信区间为1.04至1.32）。RAMPS组的一年总生存率为79.2%，而SRPS组为64.29%。该差异被认为具有统计学意义，P值为0.02。RAMPS是治疗胰体尾腺癌的一种安全手术方法。RAMPS手术在淋巴结获取和R0切除方面优于SRPS。
