Sikora Magdalena, Nicolas Céline, Istin Marine, Jaafari Nematollah, Thiriet Nathalie, Solinas Marcello
Université de Poitiers, INSERM, U1084, Laboratoire de Neurosciences Experimentales et Cliniques, France.
Université de Poitiers, INSERM, U1084, Laboratoire de Neurosciences Experimentales et Cliniques, France; Unité de Recherche Clinique Intersectorielle en Psychiatrie à vocation régionale Pierre Deniker, Centre Hospitalier Henri Laborit, Poitiers, France.
Behav Brain Res. 2018 Apr 2;341:109-113. doi: 10.1016/j.bbr.2017.12.027. Epub 2017 Dec 27.
Addiction is a chronic disease characterized by persistent vulnerability to relapse during abstinence. In animal models of addiction, accumulating evidence suggests that exposure to environmental enrichment (EE) during periods of abstinence can have curative effects on addiction and reduce the risks of relapse. However, until present most studies have mainly focused on cocaine. In this study, we investigated whether EE could have beneficial effects on cue-induced seeking for several psychoactive drugs belonging to different pharmacological classes such as methamphetamine (METH), heroin (HER) and nicotine (NIC).
After self-administration training of METH, HER and NIC, rats were housed in enriched (EE) or standard environments (SE) for 21-28 days of forced abstinence and then drug-seeking behavior was assessed in the absence of the drug.
We found that, compared to SE housing, exposure to EE reduced drug seeking behavior for all drugs tested.
These findings suggest that the anti-craving effects of EE are general for a wide variety of drugs and support the hypothesis that environmental stimulation may be a general intervention for attenuating relapse in humans.
成瘾是一种慢性疾病，其特征是在戒断期间持续存在复发的易感性。在成瘾的动物模型中，越来越多的证据表明，在戒断期间暴露于环境富集（EE）对成瘾具有治疗作用，并降低复发风险。然而，直到目前，大多数研究主要集中在可卡因上。在本研究中，我们调查了EE是否对提示诱导的几种属于不同药理学类别的精神活性药物（如甲基苯丙胺（METH）、海洛因（HER）和尼古丁（NIC））的觅药行为有有益影响。
在对METH、HER和NIC进行自我给药训练后，将大鼠置于富集（EE）或标准环境（SE）中进行21 - 28天的强制戒断，然后在无药物的情况下评估觅药行为。
我们发现，与SE饲养相比，暴露于EE减少了所有测试药物的觅药行为。
这些发现表明，EE的抗渴望作用对多种药物具有普遍性，并支持环境刺激可能是减轻人类复发的一种普遍干预措施的假设。
