对来自斯里兰卡科伦坡的714名成年人进行基于序列的HLA - A、B、C、DP、DQ和DR分型。
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.
作者信息
Grifoni Alba, Weiskopf Daniela, Lindestam Arlehamn Cecilia S, Angelo Michael, Leary Shay, Sidney John, Frazier April, Phillips Elizabeth, Mallal Simon, Mack Steven J, Tippalagama Rashmi, Goonewardana Suraj, Premawansa Sunil, Premawansa Gayani, Wijewickrama Ananda, De Silva Aruna D, Sette Alessandro
机构信息
Division of Vaccine Discovery, La Jolla Institute for Allergy & Immunology, La Jolla, CA 92037, USA.
Institute for Immunology and Infectious Diseases, Murdoch University, Perth, Western Australia 6150, Australia.
出版信息
Hum Immunol. 2018 Feb;79(2):87-88. doi: 10.1016/j.humimm.2017.12.007. Epub 2017 Dec 28.
DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proportions were not detected at any locus. Several alleles were found in >30% of individuals, including the class II alleles DPB1 * 04:01, DPB1 * 02:01, DQB1 * 06:01 and DRB1 * 07:01, and the class I alleles A * 33:03 and A * 24:02. Genotype data will be available in the Allele Frequencies Net Database.
对来自斯里兰卡科伦坡的714名健康成年血库捐献者进行了HLA - A、- B、- C、- DPB1、- DQA1、- DQB1和 - DRB1位点的基于DNA序列的分型，以确定等位基因频率，为针对包括登革热病毒在内的病原体的T细胞免疫研究提供支持。在任何位点均未检测到偏离哈迪 - 温伯格比例的情况。在超过30%的个体中发现了几个等位基因，包括II类等位基因DPB1 * 04:01、DPB1 * 02:01、DQB1 * 06:01和DRB1 * 07:01，以及I类等位基因A * 33:03和A * 24:02。基因型数据将在等位基因频率网络数据库中提供。
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