University of Nantes, Nantes, France; Nantes University Hospital, Hôtel-Dieu, Digestive Disease Institute, Gastro-Enterology, Hepatology and Digestive Oncology Unit, France.
University of Nantes, Nantes, France; Nantes University Hospital, Hôtel-Dieu, Digestive Disease Institute, Gastro-Enterology, Hepatology and Digestive Oncology Unit, France.
Dig Liver Dis. 2018 Mar;50(3):220-225. doi: 10.1016/j.dld.2017.12.004. Epub 2017 Dec 14.
The technique of hepatic arterial infusion (HAI) for the treatment of liver metastases from colorectal cancer has been developed over more than 30 years. Although the indications and protocols for this technique have evolved with time, HAI is not routinely performed in clinical practice. Studies have been heterogeneous, with different regimens of intra-arterial drugs, associated or not with systemic chemotherapy, and with unconvincing outcomes. Technical difficulties for catheter placement have limited the implementation of this method in routine practice. The aim of this review is to present recent studies, highlighting technical improvements and promising combinations of oxaliplatin-based HAI with systemic treatments. HAI is being investigated in both the metastatic setting - in the first line and beyond - and in the adjuvant setting, and we will discuss its potential place in current and future patient management.
经动脉灌注（HAI）治疗结直肠癌肝转移的技术已经发展了 30 多年。尽管该技术的适应证和方案随时间而演变，但 HAI 并未常规应用于临床实践中。这些研究具有异质性，采用了不同的动脉内药物方案，联合或不联合全身化疗，结果也不尽如人意。导管放置的技术困难限制了该方法在常规实践中的应用。本综述的目的是介绍最近的研究，重点介绍基于奥沙利铂的 HAI 与全身治疗相结合的技术改进和有前途的组合。HAI 正在转移性疾病的治疗中进行研究——包括一线治疗和更广泛的治疗——以及辅助治疗中，我们将讨论其在当前和未来患者管理中的潜在地位。
