血管加压素在新生儿重症监护病房低血压患者中的应用。
Use of Vasopressin in Neonatal Intensive Care Unit Patients With Hypotension.
作者信息
Ni Mengwei, Kaiser Jeffrey R, Moffett Brady S, Rhee Christopher J, Placencia Jennifer, Dinh Kimberly L, Hagan Joseph L, Rios Danielle R
机构信息
University of Texas Health Science Center Houston (MN), McGovern Medical School, Houston, Texas, Department of Pediatrics, Section of Neonatology (JRK, CJR, JLH, DRR), Baylor College of Medicine, Houston, Texas, Department of Obstetrics and Gynecology (JRK), Baylor College of Medicine, Houston, Texas, Department of Pharmacy (BSM, JP, KLD), Texas Children's Hospital, Houston, Texas.
出版信息
J Pediatr Pharmacol Ther. 2017 Nov-Dec;22(6):430-435. doi: 10.5863/1551-6776-22.6.430.
OBJECTIVE
To evaluate the safety and efficacy of vasopressin for the treatment of hypotension in patients admitted to neonatal intensive care units (NICUs).
METHODS
Vasopressin use in 69 infants admitted to our NICU between 2011 and 2014 was examined. Data evaluated included demographics; serum creatinine, sodium, and lactate concentrations; urine output; and systolic, diastolic, and mean blood pressures (BPs). Parameters prior to vasopressin use were compared to those at maximum dose.
RESULTS
Vasopressin use was associated with increased urine output (p < 0.05), and increased systolic (p < 0.0005), diastolic (p < 0.01), and mean (p < 0.001) BP. There were no differences in sodium or lactate concentrations before vs during infusion; vasopressin use was not associated with hyponatremia (sodium < 130 mEq/L) at the maximum dose.
CONCLUSIONS
Vasopressin for the treatment of neonatal hypotension appears safe and was efficacious in raising BP. These data suggest that vasopressin could be considered a viable option in the treatment regimen in hypotensive infants in the NICU.
目的
评估血管加压素治疗新生儿重症监护病房（NICU）患儿低血压的安全性和有效性。
方法
对2011年至2014年间入住我院NICU的69例婴儿使用血管加压素的情况进行了检查。评估的数据包括人口统计学资料；血清肌酐、钠和乳酸浓度；尿量；以及收缩压、舒张压和平均血压（BP）。将使用血管加压素前的参数与最大剂量时的参数进行比较。
结果
使用血管加压素与尿量增加（p < 0.05）以及收缩压（p < 0.0005）、舒张压（p < 0.01）和平均血压（p < 0.001）升高相关。输注前与输注期间钠或乳酸浓度无差异；最大剂量使用血管加压素与低钠血症（钠<130 mEq/L）无关。
结论
血管加压素治疗新生儿低血压似乎安全且能有效升高血压。这些数据表明，血管加压素可被视为NICU低血压婴儿治疗方案中的一个可行选择。
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