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基于A/列宁格勒/134/17/57主供体病毒的H5禽流感减毒活重配疫苗

Live Attenuated Reassortant Vaccines Based on A/Leningrad/134/17/57 Master Donor Virus Against H5 Avian Influenza.

作者信息

Kiseleva Irina, Larionova Natalie, Rudenko Larisa

机构信息

Institute of Experimental Medicine; St Petersburg, Russia.

Saint Petersburg State University, St Petersburg, Russia.

出版信息

Open Microbiol J. 2017 Nov 30;11:316-329. doi: 10.2174/1874285801711010316. eCollection 2017.

DOI:10.2174/1874285801711010316
PMID:29290844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5737031/
Abstract

BACKGROUND

The H5N1 avian influenza was first recognized in humans in Hong Kong 20 years ago. Current enzootic spread of highly pathogenic H5N1 virus among wild and domestic poultry and a number of severe human respiratory diseases caused by this pathogen have stimulated necessity of development of potentially pandemic influenza vaccines.

DISCUSSION

In the past few years, significant research was conducted on how to prevent H5N1 influenza. Live, attenuated cold-adapted reassortant influenza vaccine (LAIV) is considered as one of the most promising candidates for pandemic and prepandemic vaccines. LAIV has proven to be safe and efficacious; pandemic LAIV might be more effective than inactivated vaccine in providing broader immune response.

CONCLUSION

This review covers development of LAIVs against potential avian "pandemic" H5N1 subtype based on cold-adapted A/Leningrad/134/17/57 (H2N2) master donor virus backbone, and their preclinical and clinical studies.

摘要

背景

20年前，H5N1禽流感首次在香港被确认感染人类。目前，高致病性H5N1病毒在野生和家养禽类中呈地方性流行传播，且该病原体引发了一些严重的人类呼吸道疾病，这促使人们有必要研发具有潜在大流行可能性的流感疫苗。

讨论

在过去几年里，针对如何预防H5N1流感开展了大量研究。减毒活冷适应重配流感疫苗（LAIV）被认为是大流行和大流行前疫苗最有前景的候选疫苗之一。LAIV已被证明是安全有效的；大流行LAIV在提供更广泛免疫反应方面可能比灭活疫苗更有效。

结论

本综述涵盖了基于冷适应A/列宁格勒/134/17/57（H2N2）主供体病毒骨架研发针对潜在禽类“大流行”H5N1亚型的LAIV及其临床前和临床研究情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c2/5737031/ddfea2b3748f/TOMICROJ-11-316_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c2/5737031/a35e80a3a0f3/TOMICROJ-11-316_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c2/5737031/ddfea2b3748f/TOMICROJ-11-316_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c2/5737031/a35e80a3a0f3/TOMICROJ-11-316_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17c2/5737031/ddfea2b3748f/TOMICROJ-11-316_F2.jpg

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