Nguyen Lee S, Redheuil Alban, Mangin Olivier, Salem Joe-Elie
Department of Critical Care Medicine, CMC Ambroise Paré, Neuilly-sur-Seine 92200, France.
Sorbonne Universités, UPMC Univ Paris 06, School of Medicine, Institute of Cardiometabolism and Nutrition, Paris 75013, France.
World J Clin Cases. 2017 Dec 16;5(12):428-431. doi: 10.12998/wjcc.v5.i12.428.
Alpha-thalassemia trait and sickle trait are not commonly considered risk factors of ischemic heart disease. We report the case of a non-atherosclerotic silent myocardial infarction in a 46-year-old woman, carrier of the alpha-thalassemia trait (homozygous deletion of locus -3.7) combined with sickle cell trait. While the patient was included as healthy volunteer for a metabolic study, we performed cardiac magnetic resonance imagery showing a left ventricle apicolateral myocardial infarction. Coronary computed tomography angiography showed normal coronary arteries with a coronary calcium score of 0. The patient was treated with low-dose aspirin in secondary prevention afterwards. This case allows us to discuss cardiovascular risk among patients presenting with both alpha-thalassemia trait and sickle cell trait and the indication of cardiac imagery in such patients even when considered as low-cardiovascular risk.
α地中海贫血特征和镰状细胞特征通常不被视为缺血性心脏病的危险因素。我们报告了一名46岁女性的非动脉粥样硬化性无症状心肌梗死病例，该女性为α地中海贫血特征（-3.7位点纯合缺失）合并镰状细胞特征的携带者。当该患者作为健康志愿者纳入一项代谢研究时，我们进行了心脏磁共振成像，显示左心室心尖外侧心肌梗死。冠状动脉计算机断层扫描血管造影显示冠状动脉正常，冠状动脉钙化评分为0。此后，该患者在二级预防中接受了小剂量阿司匹林治疗。该病例使我们能够讨论同时具有α地中海贫血特征和镰状细胞特征的患者的心血管风险，以及此类患者即使被认为心血管风险较低时心脏成像的指征。
