胎盘在产前获得性寨卡病毒感染中的作用。
The role of the placenta in prenatally acquired Zika virus infection.
作者信息
Zare Mehrjardi Mohammad, Shobeirian Farzaneh
机构信息
Department of Radiology, Shohada Tajrish Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Section of Fetal Imaging, Division of Clinical Research, Climax Radiology Education Foundation, Tehran, Iran.
出版信息
Virusdisease. 2017 Sep;28(3):247-249. doi: 10.1007/s13337-017-0399-z. Epub 2017 Sep 20.
Zika virus (ZIKV) is an arthropod-borne from the family , which has been recently confirmed to cause severe neurological abnormalities (such as microcephaly, brain parenchymal calcification, hydrocephalus, and malformations of cortical development) in the infected fetuses. The Placenta plays a multifold role in prenatally acquired ZIKV infection. It serves as a port of virus transmission to the fetus, and also can be directly affected by ZIKV leading to a diminished fetal blood supply or a disrupted/changed biological mediators' synthesis. It is crucial to have a detailed knowledge about these pathomechanisms for preventing virus transmission in the infected pregnant women, as well as for prohibiting or reversing placental changes.
寨卡病毒（ZIKV）是一种节肢动物传播的病毒，属于黄病毒科，最近已证实其可导致受感染胎儿出现严重的神经异常（如小头畸形、脑实质钙化、脑积水和皮质发育畸形）。胎盘在产前获得性寨卡病毒感染中起多种作用。它是病毒传播给胎儿的通道，也可直接受到寨卡病毒影响，导致胎儿血液供应减少或生物介质合成中断/改变。详细了解这些发病机制对于预防感染孕妇的病毒传播以及阻止或逆转胎盘变化至关重要。
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