Haskins David L, Howerth Elizabeth W, Tuberville Tracey D
1 Savannah River Ecology Laboratory, University of Georgia, Aiken, SC, USA.
2 D. B. Warnell School of Forestry and Natural Resources, University of Georgia, Athens, GA, USA.
Vet Pathol. 2018 May;55(3):473-477. doi: 10.1177/0300985817750454. Epub 2018 Jan 1.
Selenosis, or selenium toxicosis, occurs in wildlife and livestock, usually because of excessive intake of selenium via selenium-containing plants. Although it is known that wild slider turtles can accumulate large amounts of selenium, little is known about how selenium exposure may affect these reptiles. In this study, the authors report histopathologic changes in yellow-bellied sliders ( Trachemys scripta scripta) caused by experimental exposure to selenomethionine. Microscopic changes in kidney and claw tissue were most significant and resembled those reported in birds. Turtles in the selenium treatment groups had acute tubular degeneration and regeneration in the kidney, with hyaline droplets in the high-dose animals, and changes in the claws ranging from epidermal hyperplasia with disorganization and intercellular edema to ulceration, and accumulation of seroheterophilic exudate between the epidermis and cornified layer. Although selenium burdens in this study are comparable with values found in wild slider turtles, more data are needed to determine if similar histopathologic abnormalities arise in wild animals exposed to high levels of selenium.
硒中毒，即硒毒症，发生于野生动物和家畜身上，通常是由于通过含硒植物过量摄入硒所致。尽管已知野生彩龟会积累大量的硒，但对于硒暴露如何影响这些爬行动物却知之甚少。在本研究中，作者报告了实验性暴露于硒代蛋氨酸导致的黄腹彩龟（滑龟指名亚种）的组织病理学变化。肾脏和爪组织的微观变化最为显著，与鸟类中报道的变化相似。硒处理组的龟肾脏出现急性肾小管变性和再生，高剂量动物出现透明滴，爪的变化范围从表皮增生伴结构紊乱和细胞间水肿到溃疡，以及表皮和角质层之间血清嗜异性渗出物的积聚。尽管本研究中的硒负荷与在野生彩龟中发现的值相当，但仍需要更多数据来确定在暴露于高水平硒的野生动物中是否会出现类似的组织病理学异常。
