Ehrensing Gordon, Craig Linden E
Veterinary Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, Lansing, MI (Ehrensing).
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN (Craig).
J Vet Diagn Invest. 2018 Mar;30(2):329-332. doi: 10.1177/1040638717752781. Epub 2018 Jan 2.
We evaluated 134 cutaneous plasmacytomas in 125 dogs submitted to the University of Tennessee surgical biopsy service between 2009 and 2012 to determine whether the presence of intravascular neoplastic cells had prognostic significance. Tumors occurred in middle-aged to geriatric dogs (range: 5-16 y, mean: 9.6 y) and most frequently involved the skin of the head and distal limbs. Diagnoses were made based on light microscopy, and in some cases confirmed by immunoreactivity of neoplastic cells for MUM1. Tumors were categorized as having or not having intravascular neoplastic cells within sections examined. The intravascular location of tumor cells was confirmed by immunoreactivity of endothelial cells for factor VIII-related antigen in 3 cases. Neoplastic cells within vessel lumens were identified in 20 of 125 dogs (16%). Submitting veterinary practices were contacted for follow-up data on patients including local recurrence and cutaneous plasmacytomas in other locations. Follow-up information was acquired on 99 dogs (79%). Recurrence was documented in one dog with cutaneous plasmacytomas; both masses had incomplete margins and intravascular neoplastic cells. Additional distant cutaneous plasmacytomas were later diagnosed in 3 patients; none of these dogs had intravascular neoplastic cells. In no cases were cutaneous plasmacytomas suspected to be a cause of death or reason for euthanasia. Intravascular neoplastic cells were more common in tumors of the distal limbs (36%) compared to other locations (11%; p = 0.0007). The presence of intravascular neoplastic cells did not affect prognosis in cutaneous plasmacytomas.
2009年至2012年间，我们对田纳西大学外科活检服务中心收治的125只犬身上的134个皮肤浆细胞瘤进行了评估，以确定血管内肿瘤细胞的存在是否具有预后意义。肿瘤发生于中年至老年犬（年龄范围：5 - 16岁，平均9.6岁），最常累及头部和四肢远端皮肤。诊断基于光学显微镜检查，部分病例通过肿瘤细胞对MUM1的免疫反应性得以证实。在所检查的切片中，肿瘤被分类为有或无血管内肿瘤细胞。3例中通过内皮细胞对VIII因子相关抗原的免疫反应性证实了肿瘤细胞的血管内位置。125只犬中有20只（16%）在血管腔内发现肿瘤细胞。我们联系了转诊的兽医诊所，获取了包括局部复发和其他部位皮肤浆细胞瘤在内的患者随访数据。99只犬（79%）获得了随访信息。有一只患皮肤浆细胞瘤的犬出现复发；两个肿块边缘均不完整且存在血管内肿瘤细胞。后来又有3例患者被诊断出远处出现皮肤浆细胞瘤；这些犬均无血管内肿瘤细胞。在任何病例中，皮肤浆细胞瘤均未被怀疑是死亡原因或安乐死的理由。与其他部位（11%；p = 0.0007）相比，血管内肿瘤细胞在四肢远端肿瘤中更为常见（36%）。血管内肿瘤细胞的存在并不影响皮肤浆细胞瘤的预后。
