CNR-IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases, Ospedali Riuniti, Reggio Calabria, Italy.
CNR-IFC, Clinical Epidemiology and Pathophysiology of Hypertension and Renal Diseases, Ospedali Riuniti, Reggio Calabria, Italy; Nephrology, Hypertension and Renal Transplantation Unit, Ospedali Riuniti, Reggio Calabria, Italy.
Kidney Int. 2018 Jan;93(1):13-15. doi: 10.1016/j.kint.2017.08.035.
In a large cohort of patients referred for the diagnosis of hypertension by ambulatory blood pressure monitoring, the risk for cardiovascular events associated with glomerular hyperfiltration (hazard ratio: 1.53) was higher than that associated with diabetes (hazard ratio: 1.43) or with a 10 mm Hg higher 24-hour systolic blood pressure (hazard ratio: 1.37) and was identical to that by smoking (hazard ratio: 1.53). Reducing glomerular hyperfiltration may improve cardiovascular outcomes in hypertensive patients, an issue that remains to be tested in appropriate randomized clinical trials.
在一个由动态血压监测诊断为高血压的大患者队列中，与肾小球滤过率升高相关的心血管事件风险（危险比：1.53）高于与糖尿病（危险比：1.43）或 24 小时收缩压升高 10mmHg（危险比：1.37）相关的风险，与吸烟（危险比：1.53）相关的风险相同。降低肾小球滤过率可能会改善高血压患者的心血管结局，但这一问题仍需在适当的随机临床试验中进行检验。
