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美国药典<800>及促进危险药物安全的策略。

USP <800> and Strategies to Promote Hazardous Drug Safety.

作者信息

Eisenberg Seth

机构信息

Seattle Cancer Care Alliance, Ambulatory Clinic, Seattle, Washington. Seth Eisenberg, ADN, RN, OCN®, BMTCN®, is a professional practice coordinator for infusion services at the Seattle Cancer Care Alliance, Ambulatory Clinic, in Seattle, Washington. He has practiced in the field of oncology since 1983. His experience includes 32 years in hematopoietic stem cell transplantation. He specializes in hazardous drug safety and has published numerous articles and book chapters on chemotherapy and biotherapy.

出版信息

J Infus Nurs. 2018 Jan/Feb;41(1):12-23. doi: 10.1097/NAN.0000000000000257.

DOI:10.1097/NAN.0000000000000257
PMID:29293194
Abstract

The term hazardous drug (HD) includes medications that have any of the following properties: carcinogenicity, teratogenicity, reproductive toxicities, genotoxicities, toxicities at low doses, and a structure that mimics other drugs meeting the criteria. Numerous studies continue to demonstrate widespread environmental contamination and human uptake of these agents. Safe handling guidelines have existed for more than 30 years but have not been routinely implemented. USP General Chapter 800 (USP <800>) represents a new enforceable standard for HD safety. Nurses will need to understand the impact of USP <800>, which is expected to be enforced beginning December 1, 2019.

摘要

“危险药物”(HD)一词包括具有以下任何特性的药物:致癌性、致畸性、生殖毒性、遗传毒性、低剂量毒性,以及具有与符合标准的其他药物相似的结构。大量研究不断表明这些药物存在广泛的环境污染以及人体摄入情况。安全操作指南已经存在30多年了,但尚未得到常规执行。美国药典通则第800章(USP <800>)代表了一项新的危险药物安全可执行标准。护士需要了解USP <800>的影响,该标准预计于2019年12月1日开始实施。

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