Takeishi Ryosuke, Magara Jin, Watanabe Masahiro, Tsujimura Takanori, Hayashi Hirokazu, Hori Kazuhiro, Inoue Makoto
Division of Dysphagia Rehabilitation, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, Japan.
Division of Comprehensive Prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274 Gakkocho-dori, Chuo-ku, Niigata, Japan.
PLoS One. 2018 Jan 2;13(1):e0190608. doi: 10.1371/journal.pone.0190608. eCollection 2018.
Pharyngeal electrical stimulation (PEStim) has been found to facilitate voluntary swallowing. This study investigated how PEStim contributed to modulation of swallowing function in 15 healthy humans. In the involuntary swallowing test, water was injected onto the pharynx at 0.05 ml/s and the onset latency of the first swallow was measured. In the voluntary swallowing test, subjects swallowed their own saliva as quickly as possible for 30 s and the number of swallows was counted. Voluntary and involuntary swallowing was evaluated before (baseline), immediately after, and every 10 min after 10-min PEStim for 60 min. A voluntary swallowing test with simultaneous 30-s PEStim was also conducted before and 60 min after 10-min PEStim. The number of voluntary swallows with simultaneous PEStim significantly increased over 60 min after 10-min PEStim compared with the baseline. The onset latency of the first swallow in the involuntary swallowing test was not affected by 10-min PEStim. The results suggest that PEStim may have a long-term facilitatory effect on the initiation of voluntary swallowing in healthy humans, but not on peripherally-evoked swallowing. The physiological implications of this modulation are discussed.
咽电刺激（PEStim）已被发现有助于促进自主吞咽。本研究调查了PEStim如何影响15名健康人的吞咽功能调节。在非自主吞咽测试中，以0.05 ml/s的速度将水注入咽部，并测量首次吞咽的起始潜伏期。在自主吞咽测试中，受试者在30秒内尽可能快地吞咽自己的唾液，并计算吞咽次数。在10分钟的PEStim前（基线）、刚结束后以及之后每10分钟持续60分钟对自主和非自主吞咽进行评估。在10分钟的PEStim前和60分钟后还进行了同时进行30秒PEStim的自主吞咽测试。与基线相比，10分钟的PEStim后60分钟内，同时进行PEStim时的自主吞咽次数显著增加。非自主吞咽测试中首次吞咽的起始潜伏期不受10分钟PEStim的影响。结果表明，PEStim可能对健康人的自主吞咽起始有长期促进作用，但对外周诱发的吞咽没有作用。本文讨论了这种调节的生理意义。
