不同剂量维生素D对母乳喂养婴儿骨代谢的影响缺乏效应
Lack of Effect of Graded Doses of Vitamin D on Bone Metabolism of Breastfed Infants.
作者信息
Ziegler Ekhard E, Koo Winston Wk, Nelson Steven E, Jeter Janice M
机构信息
Department of Pediatrics, University of Iowa, USA.
Department of Pediatrics, Louisiana State University Health Sciences Center, USA.
出版信息
J Clin Nutr Metab. 2017;1(1). Epub 2017 Sep 27.
OBJECTIVE
A range of doses of supplemental vitamin D has been shown to be effective in preventing rickets in breastfed infants, but the effect of different doses of vitamin D on bone metabolism and mineral content has not been delineated.
METHODS
In a randomized trial, breastfed infants received from 2 to 9 months daily supplements of vitamin D in doses of 200 IU/d, 400 IU/d, 600 IU/d or 800 IU/d. Measures of bone metabolism (plasma) were determined periodically and bone mineral content (DXA) was determined at study entry and at the end of winter when infants were 5.5 to 9 months old. The main findings have been reported; here we report findings related to bone metabolism.
RESULTS
There were no consistent meaningful effects of vitamin D dose on markers of bone metabolism. Some markers showed changes with age. Bone mineral content increased with age but showed no effect of vitamin D dose.
CONCLUSION
Vitamin D in daily doses from 200 IU/d to 800 IU/d had no measurable effect on bone mineral content or bone metabolism of breastfed infants.
目的
一系列剂量的补充维生素D已被证明对预防母乳喂养婴儿的佝偻病有效，但不同剂量的维生素D对骨代谢和矿物质含量的影响尚未明确。
方法
在一项随机试验中，母乳喂养的婴儿在2至9个月期间每天接受200国际单位/天、400国际单位/天、600国际单位/天或800国际单位/天剂量的维生素D补充剂。定期测定骨代谢指标（血浆），并在研究开始时以及婴儿5.5至9个月大的冬季末测定骨矿物质含量（双能X线吸收法）。主要研究结果已发表；在此我们报告与骨代谢相关的研究结果。
结果
维生素D剂量对骨代谢标志物没有一致的显著影响。一些标志物随年龄变化。骨矿物质含量随年龄增加，但未显示出维生素D剂量的影响。
结论
每天200国际单位/天至800国际单位/天剂量的维生素D对母乳喂养婴儿的骨矿物质含量或骨代谢没有可测量的影响。
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