Banaszczak Marcin, Stachowska Ewa
Department of Biochemistry and Human Nutrition, Pomeranian Medical University, Broniewskiego 24,71-460 Szczecin, Poland.
Postepy Biochem. 2017;63(3):190-197.
Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the world. Nowadays, the number of people with type II diabetes and hypertension is growing. These symptoms belong to metabolic syndrome and the liver manifestation of this disease is NAFLD. Most people suffering from NAFLD are obese but this disease can also affect the lean individuals. This disease in extreme cases can lead to liver fibrosis and cirrhosis. Although NAFLD remains largely asymptomatic for the most of the time it can progress to a severe form of disease called nonalcoholic steatohepatitis (NASH) or even hepatocellular carcinoma. In this review we describe a role of factors that influence NAFLD pathogenesis such as: insulin resistance, epigenetic factors, adipokine dysfunction, intestinal flora disorder, oxidative stress and markers of inflammatory states in the form of fatty acid derivatives.
非酒精性脂肪性肝病（NAFLD）是世界上最常见的肝脏疾病之一。如今，II型糖尿病和高血压患者的数量正在增加。这些症状属于代谢综合征，而该疾病的肝脏表现就是NAFLD。大多数患有NAFLD的人都肥胖，但这种疾病也会影响体型偏瘦的个体。在极端情况下，这种疾病会导致肝纤维化和肝硬化。尽管NAFLD在大多数时候基本没有症状，但它可能会发展成一种严重的疾病形式，即非酒精性脂肪性肝炎（NASH），甚至肝细胞癌。在这篇综述中，我们描述了影响NAFLD发病机制的因素所起的作用，这些因素包括：胰岛素抵抗、表观遗传因素、脂肪因子功能障碍、肠道菌群紊乱、氧化应激以及以脂肪酸衍生物形式存在的炎症状态标志物。
