Hu Q, Jiang C Q, Zhang W S, Cheng J J, Xu L, Jin Y L, Shen Z M, Zhu F, Lam D Q
Molecular Epidemiology Research Center, Guangzhou Twelfth People's Hospital, Guangzhou 510620, China.
Department of Public Health and Epidemiology, University of Birmingham, Birmingham B15 2TT, UK.
Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Dec 10;38(12):1699-1702. doi: 10.3760/cma.j.issn.0254-6450.2017.12.023.
To examine the association between weight changes during early and middle adulthood and the risk of type 2 diabetes mellitus in middle aged and elderly population. Based on the Guangzhou Biobank Cohort Study (GBCS), 28 736 residents aged ≥50 years were included in Guangzhou. Multivariate logistic regression was used to analyze the association between body weight changes during early or middle adulthood and age when the heaviest weight reaching the threshold on the risk of type 2 diabetes mellitus in middle age or elderly population. Adjustments on age, smoking, alcohol consumption, physical activity, education level, occupation, district of residence and body mass index ., were made. The mean age was 64.3 (standard deviation=6.7) years in men and 61.0 (standard deviation=7.0) years in women, with the prevalence rates of diabetes as 13.1% and 13.7% in men and women, respectively. Compared to those with stable body weight, the risk of diabetes increased with weight gain during early and middle adulthood in both men and women (both values for trend<0.01). Participants who gained more than 20 kg during early and middle adulthood were associated with the highest risk of diabetes in men (=2.83, 95%:1.99-4.02) and women (=3.13, 95%: 2.47-3.96). Compared to those who reached the highest weight at age 20, those who reaching the highest weight at 40 to 49 years were associated with the highest risk of diabetes, with being 5.32 (95%: 1.92-14.8) in men and 3.41 (95%: 2.49-4.67) in women, respectively. Weight loss in adulthood was associated with self-reported but not newly diagnosed diabetic cases in both middle and older aged men and women. Weight gain during early and middle adulthood may increase the risk of diabetes in middle and older aged population. The detrimental effect of obesity on diabetes might become significantly visible in the next decades.
研究成年早期和中期体重变化与中老年人群2型糖尿病风险之间的关联。基于广州生物样本库队列研究（GBCS），纳入了广州28736名年龄≥50岁的居民。采用多因素logistic回归分析成年早期或中期体重变化以及体重达到阈值时的年龄与中老年人群2型糖尿病风险之间的关联。对年龄、吸烟、饮酒、体力活动、教育水平、职业、居住地区和体重指数等进行了调整。男性的平均年龄为64.3（标准差 = 6.7）岁，女性为61.0（标准差 = 7.0）岁，男性和女性的糖尿病患病率分别为13.1%和13.7%。与体重稳定者相比，成年早期和中期体重增加的男性和女性患糖尿病的风险均增加（趋势检验P值均<0.01）。成年早期和中期体重增加超过20 kg的参与者患糖尿病的风险最高，男性的比值比（OR）=2.83，95%置信区间（CI）：1.99 - 4.02；女性的OR = 3.13，95%CI：2.47 - 3.96。与20岁时达到最高体重者相比，40至49岁时达到最高体重者患糖尿病的风险最高，男性的OR为5.32（95%CI：1.92 - 14.8），女性为3.41（95%CI：2.49 - 4.67）。成年期体重减轻与中老年男性和女性自我报告的而非新诊断的糖尿病病例有关。成年早期和中期体重增加可能会增加中老年人群患糖尿病的风险。肥胖对糖尿病的有害影响可能在未来几十年变得更加明显。
