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宫内暴露于环境细颗粒物空气污染是孟加拉国儿童发育迟缓的一个风险因素。

Exposure to Ambient Fine Particulate Air Pollution in Utero as a Risk Factor for Child Stunting in Bangladesh.

机构信息

Lee Kuan Yew School of Public Policy, National University of Singapore, Singapore 259772, Singapore.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

出版信息

Int J Environ Res Public Health. 2017 Dec 23;15(1):22. doi: 10.3390/ijerph15010022.

Abstract

Pregnant mothers in Bangladesh are exposed to very high and worsening levels of ambient air pollution. Maternal exposure to fine particulate matter has been associated with low birth weight at much lower levels of exposure, leading us to suspect the potentially large effects of air pollution on stunting in children in Bangladesh. We estimate the relationship between exposure to air pollution in utero and child stunting by pooling outcome data from four waves of the nationally representative Bangladesh Demographic and Health Survey conducted between 2004 and 2014, and calculating children's exposure to ambient fine particulate matter in utero using high resolution satellite data. We find significant increases in the relative risk of child stunting, wasting, and underweight with higher levels of in utero exposure to air pollution, after controlling for other factors that have been found to contribute to child anthropometric failure. We estimate the relative risk of stunting in the second, third, and fourth quartiles of exposure as 1.074 (95% confidence interval: 1.014-1.138), 1.150 (95% confidence interval: 1.069-1.237, and 1.132 (95% confidence interval: 1.031-1.243), respectively. Over half of all children in Bangladesh in our sample were exposed to an annual ambient fine particulate matter level in excess of 46 µg/m³; these children had a relative risk of stunting over 1.13 times that of children in the lowest quartile of exposure. Reducing air pollution in Bangladesh could significantly contribute to the Sustainable Development Goal of reducing child stunting.

摘要

孟加拉国的孕妇暴露在极高且不断恶化的环境空气污染水平下。母体暴露于细颗粒物与低出生体重有关,而暴露于低水平的细颗粒物也会导致这种情况,这使我们怀疑空气污染对孟加拉国儿童发育迟缓的潜在巨大影响。我们通过汇总 2004 年至 2014 年间进行的四次具有全国代表性的孟加拉国人口与健康调查的结果数据,并使用高分辨率卫星数据计算胎儿暴露于环境细颗粒物的情况,来估计胎儿期暴露于空气污染与儿童发育迟缓之间的关系。我们发现,在控制其他已知会导致儿童体格发育失败的因素后,随着胎儿期暴露于空气污染水平的升高,儿童发育迟缓、消瘦和体重不足的相对风险显著增加。我们估计暴露于第二、第三和第四四分位数的相对风险分别为 1.074(95%置信区间:1.014-1.138)、1.150(95%置信区间:1.069-1.237)和 1.132(95%置信区间:1.031-1.243)。我们样本中超过一半的孟加拉国儿童每年都暴露于超过 46 µg/m³的环境细颗粒物水平;这些儿童的发育迟缓相对风险是暴露于最低四分位数儿童的 1.13 倍以上。减少孟加拉国的空气污染可以为减少儿童发育迟缓的可持续发展目标做出重大贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c68b/5800122/32b49c434d46/ijerph-15-00022-g001.jpg

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