达那唑所致胆汁淤积
Danazol-induced cholestasis.
作者信息
Silva M O, Reddy K R, McDonald T, Jeffers L J, Schiff E R
机构信息
Center for Liver Diseases, University of Miami School of Medicine, VA Medical Center, Florida.
出版信息
Am J Gastroenterol. 1989 Apr;84(4):426-8.
PMID:2929566
Abstract
A 39-yr-old female on high-dose Danazol presented with jaundice and pruritus. Danazol-induced cholestasis was suspected, and the drug was discontinued. A liver biopsy revealed panlobular cholestasis with portal and periportal inflammation. The cholestasis resolved completely in 8 wk. This is a rare case of Danazol-induced cholestasis and should be considered in the differential diagnosis of drug-induced liver injury.
摘要
一名39岁服用大剂量达那唑的女性出现黄疸和瘙痒。怀疑是达那唑引起的胆汁淤积，遂停用该药。肝脏活检显示全小叶胆汁淤积伴门管区和门管周围炎症。胆汁淤积在8周内完全消退。这是一例罕见的达那唑引起的胆汁淤积病例，在药物性肝损伤的鉴别诊断中应予以考虑。
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引用本文的文献
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World J Gastroenterol. 2009 Jun 21;15(23):2817-33. doi: 10.3748/wjg.15.2817.
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