Interdisciplinary Brain Research Centre, J.N Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, India.
Curr Cancer Drug Targets. 2020;20(5):335-340. doi: 10.2174/1568009618666180102111539.
Complex central nervous system (CNS) is made up of neuronal cells and glial cells. Cells of central nervous system are able to regenerate after injury and during repairing. Sonic hedgehog pathway initiated by Shh-N a glycoprotein plays vital role in CNS patterning growth, development and now tumorigenesis. Nkx2.2 homeodomain transcription factor is an effecter molecule, which is positively regulated by Shh during normal growth. Nkx2.2 is essential for V3 domain specification during neural tube patterning at embryonic stage. MBP + oligodendrocytes are differentiated from progenitor cells which express Olig2. Nx2.2 is co-expressed with Olig2 in oligodendrocytes and is essential for later stage of oligodendrocyte maturation.
This review paper explores the potential role of Nkx2.2 transcription factor in glioblastoma development.
Shh pathway plays a vital role in oligodendrocytes differentiation and Nkx2.2 transcription factor is essential for oligodendrocytes differentiation and maturation. Intriguingly, down regulation of Nkx2.2 transcription factor with aberrant Shh signaling pathway is reported in glioma samples. So here it is suggested that Nkx2.2 expression pattern could be used as a potential biomarker for the early diagnosis of glioma.
复杂的中枢神经系统（CNS）由神经元细胞和神经胶质细胞组成。中枢神经系统的细胞在受伤后和修复过程中能够再生。Shh-N 一种糖蛋白启动的 Sonic hedgehog 途径在中枢神经系统的模式形成、生长、发育和现在的肿瘤发生中起着至关重要的作用。Nkx2.2 同源域转录因子是一种效应分子，在正常生长过程中受 Shh 正向调节。Nkx2.2 对于胚胎期神经管模式形成中的 V3 结构域的特化是必需的。MBP+少突胶质细胞是由表达 Olig2 的祖细胞分化而来的。Nx2.2 在少突胶质细胞中与 Olig2 共表达，对于少突胶质细胞的后期成熟是必需的。
本文探讨了 Nkx2.2 转录因子在胶质母细胞瘤发生中的潜在作用。
Shh 途径在少突胶质细胞分化中起着至关重要的作用，Nkx2.2 转录因子对于少突胶质细胞的分化和成熟是必需的。有趣的是，在神经胶质瘤样本中报道了 Shh 信号通路异常导致 Nkx2.2 转录因子下调。因此，这里提出 Nkx2.2 表达模式可以作为神经胶质瘤早期诊断的潜在生物标志物。
