活化蛋白C轻链为其抗凝辅助因子蛋白S提供了一个扩展的结合表面。
Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S.
作者信息
Fernández José A, Xu Xiao, Sinha Ranjeet K, Mosnier Laurent O, Sanner Michel F, Griffin John H
机构信息
Department of Molecular Medicine and.
Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA.
出版信息
Blood Adv. 2017 Aug 7;1(18):1423-1426. doi: 10.1182/bloodadvances.2017007005. eCollection 2017 Aug 8.
Abstract
Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.
摘要
对9种重组活化蛋白C（APC）突变体进行了蛋白S抗凝辅因子敏感性和蛋白酶激活受体1（PAR1）裂解活性检测。APC轻链一侧的第38位亮氨酸、第43位赖氨酸、第73位异亮氨酸、第95位苯丙氨酸和第115位色氨酸残基构成了一个包含蛋白S结合位点的延伸表面。
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