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ATG in allogeneic stem cell transplantation: standard of care in 2017? Point.异基因干细胞移植中的抗胸腺细胞球蛋白：2017年的治疗标准？观点。
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Impact of anti-thymocyte globulin dose for graft-versus-host disease prophylaxis in allogeneic hematopoietic cell transplantation from matched unrelated donors: a multicenter experience.同种异体造血细胞移植中抗胸腺细胞球蛋白剂量预防移植物抗宿主病的影响：一项多中心经验。
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Factors Associated with Post-Transplant Active Epstein-Barr Virus Infection and Lymphoproliferative Disease in Hematopoietic Stem Cell Transplant Recipients: A Systematic Review and Meta-Analysis.造血干细胞移植受者移植后活动性EB病毒感染和淋巴增殖性疾病的相关因素：一项系统评价和荟萃分析
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本文引用的文献

1
Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.抗T淋巴细胞球蛋白用于评估对接受HLA匹配的非血缘清髓性造血细胞移植患者慢性移植物抗宿主病无病生存影响的前瞻性、随机、双盲、III期临床试验。
J Clin Oncol. 2017 Dec 20;35(36):4003-4011. doi: 10.1200/JCO.2017.75.8177. Epub 2017 Oct 17.
2
Excellent T-cell reconstitution and survival depend on low ATG exposure after pediatric cord blood transplantation.优秀的 T 细胞重建和存活依赖于儿童脐带血移植后低 ATG 暴露。
Blood. 2016 Dec 8;128(23):2734-2741. doi: 10.1182/blood-2016-06-721936. Epub 2016 Oct 4.
3
Individualized conditioning regimes in cord blood transplantation: Towards improved and predictable safety and efficacy.脐血移植中的个体化预处理方案：提高和预测安全性和疗效。
Expert Opin Biol Ther. 2016 Jun;16(6):801-13. doi: 10.1517/14712598.2016.1164688. Epub 2016 Mar 28.
4
Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.抗淋巴细胞球蛋白预防慢性移植物抗宿主病。
N Engl J Med. 2016 Jan 7;374(1):43-53. doi: 10.1056/NEJMoa1506002.
5
Pretreatment with anti-thymocyte globulin versus no anti-thymocyte globulin in patients with haematological malignancies undergoing haemopoietic cell transplantation from unrelated donors: a randomised, controlled, open-label, phase 3, multicentre trial.预处理用抗胸腺细胞球蛋白与无抗胸腺细胞球蛋白在异基因造血细胞移植治疗血液系统恶性肿瘤患者中的随机、对照、开放标签、3 期、多中心试验。
Lancet Oncol. 2016 Feb;17(2):164-173. doi: 10.1016/S1470-2045(15)00462-3. Epub 2015 Dec 24.
6
Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis.抗胸腺细胞球蛋白暴露与儿童造血细胞移植中CD4+免疫重建的关联：一项多中心回顾性药效学队列分析
Lancet Haematol. 2015 May;2(5):e194-203. doi: 10.1016/S2352-3026(15)00045-9. Epub 2015 Apr 21.
7
Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia.单倍体相合移植联合移植后环磷酰胺与匹配无关供者移植治疗急性髓系白血病
Blood. 2015 Aug 20;126(8):1033-40. doi: 10.1182/blood-2015-04-639831. Epub 2015 Jun 30.
8
Multi-institutional study of post-transplantation cyclophosphamide as single-agent graft-versus-host disease prophylaxis after allogeneic bone marrow transplantation using myeloablative busulfan and fludarabine conditioning.使用白消安和氟达拉滨进行清髓预处理后，将移植后环磷酰胺作为预防异基因骨髓移植后移植物抗宿主病的单一药物的多机构研究。
J Clin Oncol. 2014 Nov 1;32(31):3497-505. doi: 10.1200/JCO.2013.54.0625. Epub 2014 Sep 29.
9
Validation and refinement of the Disease Risk Index for allogeneic stem cell transplantation.异体造血干细胞移植疾病风险指数的验证和优化。
Blood. 2014 Jun 5;123(23):3664-71. doi: 10.1182/blood-2014-01-552984. Epub 2014 Apr 17.
10
Rabbit anti-T-lymphocyte globulin (ATG) persists with differential reactivity in patients' sera after full hematopoetic regeneration from allogeneic stem cell transplantation.兔抗 T 淋巴细胞球蛋白（ATG）在异基因干细胞移植后完全造血重建后，在患者血清中仍保持差异反应性。
Transpl Immunol. 2014 May;30(4):136-9. doi: 10.1016/j.trim.2014.03.005. Epub 2014 Apr 13.

异基因干细胞移植中的抗胸腺细胞球蛋白：2017年的治疗标准？反对观点。

ATG in allogeneic stem cell transplantation: standard of care in 2017? Counterpoint.

作者信息

Kekre Natasha, Antin Joseph H

机构信息

Blood and Marrow Transplant Program, The Ottawa Hospital, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada; and.

Stem Cell Transplantation Program, Division of Hematologic Malignancies, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

出版信息

Blood Adv. 2017 Mar 28;1(9):573-576. doi: 10.1182/bloodadvances.2016001552.

DOI:10.1182/bloodadvances.2016001552
PMID:29296977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5728595/
Abstract

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