使用离体肺模型在超低剂量CT中检测人工肺结节。
Detection of artificial pulmonary lung nodules in ultralow-dose CT using an ex vivo lung phantom.
作者信息
Burgard Caroline Alexandra, Gaass Thomas, Bonert Madeleine, Bondesson David, Thaens Natalie, Reiser Maximilian Ferdinand, Dinkel Julien
机构信息
Department of Clinical Radiology, University Hospital Munich, Ludwig-Maximilians-University, Munich, Germany.
Comprehensive Pneumology Center, German Center for Lung Research, Munich, Germany.
出版信息
PLoS One. 2018 Jan 3;13(1):e0190501. doi: 10.1371/journal.pone.0190501. eCollection 2018.
OBJECTIVES
To assess the image quality of 3 different ultralow-dose CT protocols on pulmonary nodule depiction in a ventilated ex vivo-system.
MATERIALS AND METHODS
Four porcine lungs were inflated inside a dedicated chest phantom and prepared with n = 195 artificial nodules (0.5-1 mL). The artificial chest wall was filled with water to simulate the absorption of a human chest. Images were acquired with a 2x192-row detector CT using low-dose (reference protocol with a tube voltage of 120 kV) and 3 different ULD protocols (respective effective doses: 1mSv and 0.1mSv). A different tube voltage was used for each ULD protocol: 70kV, 100kV with tin filter (100kV_Sn) and 150kV with tin filter (150kV_Sn). Nodule delineation was assessed by two observers (scores 1-5, 1 = unsure, 5 = high confidence).
RESULTS
The diameter of the 195 detected artificial nodules ranged from 0.9-21.5 mm (mean 7.84 mm ± 5.31). The best ULD scores were achieved using 100kV_Sn and 70 kV ULD protocols (4.14 and 4.06 respectively). Both protocols were not significantly different (p = 0.244). The mean score of 3.78 in ULD 150kV_Sn was significantly lower compared to the 100kV_Sn ULD protocol (p = 0.008).
CONCLUSION
The results of this experiment, conducted in a realistic setting show the feasibility of ultralow-dose CT for the detection of pulmonary nodules.
目的
评估3种不同超低剂量CT方案在通气离体系统中对肺结节的显示图像质量。
材料与方法
在专用胸部模型内对4个猪肺进行充气，并植入n = 195个模拟人工结节（0.5 - 1 mL）。人工胸壁用水填充以模拟人体胸部的吸收情况。使用2x192排探测器CT，采用低剂量（管电压120 kV的参考方案）和3种不同的超低剂量方案（各自有效剂量：1 mSv和0.1 mSv）采集图像。每种超低剂量方案使用不同的管电压：70 kV、带锡滤过器的100 kV（100kV_Sn）和带锡滤过器的150 kV（150kV_Sn）。由两名观察者评估结节的勾画情况（评分1 - 5，1 = 不确定，5 = 高度确信）。
结果
检测到的195个模拟人工结节直径范围为0.9 - 21.5 mm（平均7.84 mm ± 5.31）。使用100kV_Sn和70 kV超低剂量方案获得了最佳分数（分别为4.14和4.06）。两种方案无显著差异（p = 0.244）。与100kV_Sn超低剂量方案相比，150kV_Sn超低剂量方案的平均分数3.78显著更低（p = 0.008）。
结论
在实际环境中进行的本实验结果表明，超低剂量CT检测肺结节具有可行性。
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