Ctf18-RFC 的双重角色：加载夹钳并为聚合酶调整角度。
Dual Roles of Ctf18-RFC: Loading the Clamp and Angling for the Polymerase.
机构信息
Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
出版信息
Structure. 2018 Jan 2;26(1):1-2. doi: 10.1016/j.str.2017.12.009.
PMID:29298409
Abstract
Clamp loaders such as Ctf18-RFC assist DNA replication by loading the PCNA clamp onto DNA. In this issue of Structure, Grabarczyk et al. (2018) reveal that a hook-like structure formed by the unique Dcc1 and Ctf8 subunits mediates the interaction of Ctf18-RFC with the leading strand DNA polymerase ɛ.
摘要
夹子加载器（如 Ctf18-RFC）通过将 PCNA 夹子加载到 DNA 上来辅助 DNA 复制。在本期的《结构》杂志中，Grabarczyk 等人（2018 年）揭示了由独特的 Dcc1 和 Ctf8 亚基形成的钩状结构介导了 Ctf18-RFC 与前导链 DNA 聚合酶 ɛ 的相互作用。
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