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勒米尔综合征:一种后果严重的颈部疼痛。

Lemierre's syndrome: a pain in the neck with far-reaching consequences.

作者信息

Stubington Thomas James, James Paul

机构信息

ENT, Queen's Medical Centre Nottingham, Nottingham, UK.

Critical Care, Queen's Medical Centre Nottingham, Nottingham, UK.

出版信息

BMJ Case Rep. 2018 Jan 3;2018:bcr-2017-222723. doi: 10.1136/bcr-2017-222723.

DOI:10.1136/bcr-2017-222723
PMID:29298792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5775790/
Abstract

Lemierre's syndrome is a potentially life-threatening consequence of oropharyngeal and ear infections and often results in critical care admission and even intubation. Due to the multisystem manifestation, multiple teams may initially be involved in the care, some of which may be unfamiliar with the features and usual clinical course. This report describes a case in a 36-year-old woman with the classic features of internal jugular vein thrombosis and septic emboli to the lungs secondary to an oropharyngeal infection. Treatment comprised antibiotic therapy, anticoagulation and fluid resuscitation, and was carried out in a high dependency unit setting. At follow-up 3 months after discharge, the patient was well with no residual symptoms off all treatment. During the events of this case, it became apparent that while ear, nose and throat and infectious diseases team members were relatively familiar with the condition, other departments including the critical care team were less so.

摘要

勒米尔综合征是口咽和耳部感染可能危及生命的后果,常导致重症监护病房收治,甚至需要插管。由于其多系统表现,最初可能有多个团队参与治疗,其中一些团队可能不熟悉其特征和常见临床病程。本报告描述了一名36岁女性的病例,该患者具有颈内静脉血栓形成和口咽感染继发肺部脓毒性栓子的典型特征。治疗包括抗生素治疗、抗凝和液体复苏,在高依赖病房进行。出院后3个月随访时,患者情况良好,停用所有治疗后无残留症状。在该病例过程中,很明显,虽然耳鼻喉科和传染病科团队成员对该疾病相对熟悉,但包括重症监护团队在内的其他科室则不然。

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本文引用的文献

1
To anticoagulate? Controversy in the management of thrombotic complications of head & neck infections.进行抗凝治疗?头颈部感染血栓性并发症管理中的争议。
Int J Pediatr Otorhinolaryngol. 2016 Sep;88:129-35. doi: 10.1016/j.ijporl.2016.06.013. Epub 2016 Jun 6.
2
Septic thrombosis of the internal jugular vein: Lemierre's syndrome revisited.颈内静脉脓毒性血栓形成:再探勒米尔综合征
Laryngoscope. 2015 Apr;125(4):863-8. doi: 10.1002/lary.24995. Epub 2014 Nov 12.
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Incidence and microbiology of peritonsillar abscess: the influence of season, age, and gender.扁桃体周围脓肿的发病率及微生物学:季节、年龄和性别的影响
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Use of anticoagulation therapy for jugular vein thrombus in pediatric patients with Lemierre's syndrome.小儿莱姆病综合征并发颈静脉血栓形成的抗凝治疗。
Int J Clin Pharm. 2012 Dec;34(6):818-21. doi: 10.1007/s11096-012-9684-5. Epub 2012 Aug 17.
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Epidemiology and clinical outcomes of patients with Fusobacterium bacteraemia.梭杆菌菌血症患者的流行病学和临床结局。
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Extra-corporeal membrane oxygenation in a patient with Fusobacterium sepsis: a case report and review of literature.一名梭状芽孢杆菌败血症患者的体外膜肺氧合:病例报告及文献综述
Ann Thorac Cardiovasc Surg. 2011;17(4):397-9. doi: 10.5761/atcs.cr.10.01587.
7
Lemierre's syndrome: A systematic review.勒米尔综合征:一项系统评价。
Laryngoscope. 2009 Aug;119(8):1552-9. doi: 10.1002/lary.20542.
8
Lemierre's syndrome: what are the roles for anticoagulation and long-term antibiotic therapy?勒米尔综合征:抗凝治疗和长期抗生素治疗的作用是什么?
Ann Otol Rhinol Laryngol. 2008 Sep;117(9):679-83. doi: 10.1177/000348940811700909.
9
Intravenous heparin in combination with antibiotics for the treatment of deep vein septic thrombophlebitis: a systematic review.静脉注射肝素联合抗生素治疗深部静脉感染性血栓性静脉炎:一项系统评价
Eur J Pharmacol. 2007 Feb 28;557(2-3):93-8. doi: 10.1016/j.ejphar.2006.11.068. Epub 2006 Dec 12.
10
Human infections with Fusobacterium necrophorum.人类坏死梭杆菌感染。
Anaerobe. 2006 Aug;12(4):165-72. doi: 10.1016/j.anaerobe.2005.11.003. Epub 2005 Dec 22.