Graduate Program in Neuroscience University of Washington Seattle WA USA.
Center for Sensorimotor Neural Engineering University of Washington Seattle WA USA.
Brain Behav. 2017 Nov 22;7(12):e00863. doi: 10.1002/brb3.863. eCollection 2017 Dec.
Resting-state connectivity patterns have been observed in humans and other mammal species, and can be recorded using a variety of different technologies. Functional connectivity has been previously compared between species using resting-state fMRI, but not in electrophysiological studies.
We compared connectivity with implanted electrodes in humans (electrocorticography) to macaques and sheep (microelectrocorticography), which are capable of recording neural data at high frequencies with spatial precision. We specifically examined synchrony, implicated in functional integration between regions.
We found that connectivity strength was overwhelmingly similar in humans and monkeys for pairs of two different brain regions (prefrontal, motor, premotor, parietal), but differed more often within single brain regions. The two connectivity measures, correlation and phase locking value, were similar in most comparisons. Connectivity strength agreed more often between the species at higher frequencies. Where the species differed, monkey synchrony was stronger than human in all but one case. In contrast, human and sheep connectivity within somatosensory cortex diverged in almost all frequencies, with human connectivity stronger than sheep.
Our findings imply greater heterogeneity within regions in humans than in monkeys, but comparable functional interactions between regions in the two species. This suggests that monkeys may be effectively used to probe resting-state connectivity in humans, and that such findings can then be validated in humans. Although the discrepancy between humans and sheep is larger, we suggest that findings from sheep in highly invasive studies may be used to provide guidance for studies in other species.
在人类和其他哺乳动物中观察到了静息状态连接模式，可以使用各种不同的技术进行记录。以前已经使用静息态 fMRI 比较了不同物种之间的功能连接，但在电生理研究中没有比较过。
我们比较了人类（皮层脑电图）与猕猴和绵羊（微皮层脑电图）的连接，后两者能够以高空间精度记录高频神经数据。我们特别研究了同步性，它与区域之间的功能整合有关。
我们发现，对于不同大脑区域（前额叶、运动、运动前叶、顶叶）的两个配对，人类和猴子之间的连接强度非常相似，但在单个大脑区域内差异更大。两种连接测量方法，相关和锁相值，在大多数比较中都很相似。在更高频率下，物种间的连接强度更一致。在物种差异的情况下，除了一种情况外，猴子的同步性都比人类更强。相比之下，人类和绵羊的躯体感觉皮层内的连接在几乎所有频率上都不同，人类的连接比绵羊更强。
我们的研究结果表明，人类大脑区域内的异质性比猴子更大，但两种物种之间的区域功能相互作用相当。这表明猴子可以有效地用于探测人类的静息状态连接，并且这些发现可以在人类中进行验证。尽管人类和绵羊之间的差异更大，但我们建议可以使用绵羊的高度侵入性研究结果来为其他物种的研究提供指导。
