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Unravelling the mysterious onchocerciasis-nodding syndrome link: new developments and future challenges.

作者信息

Kakooza-Mwesige Angelina

机构信息

Department of Paediatrics & Child Health, Makerere University College of Health Sciences, Kampala, Uganda.

Astrid Lindgren Children's Hospital, Department of Women's & Children's Health, Neuropediatric Research Unit, Karolinska Institutet, Stockholm, Sweden.

出版信息

Ann Transl Med. 2017 Dec;5(24):486. doi: 10.21037/atm.2017.09.36.

DOI:10.21037/atm.2017.09.36
PMID:29299448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5750291/
Abstract
摘要

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Unravelling the mysterious onchocerciasis-nodding syndrome link: new developments and future challenges.揭开盘尾丝虫病-点头综合征关联之谜:新进展与未来挑战
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Persons with onchocerciasis-associated epilepsy and nodding seizures have a more severe form of epilepsy with more cognitive impairment and higher levels of Onchocerca volvulus infection.患有盘尾丝虫病相关癫痫和点头样癫痫发作的人患有更严重形式的癫痫,伴有更多认知障碍和更高水平的旋盘尾丝虫感染。
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引用本文的文献

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Economic burden of the persistent morbidity of nodding syndrome on caregivers in affected households in Northern Uganda.乌干达北部受点头综合征影响家庭中照顾者持续性发病的经济负担。
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2
Onchocerciasis-Associated Epilepsy with Head Nodding Seizures-Nodding Syndrome: A Case Series of 15 Patients from Western Uganda, 1994.盘尾丝虫病相关癫痫伴头部点头发作-点头综合征:来自乌干达西部的 15 例患者的病例系列,1994 年。
Am J Trop Med Hyg. 2018 Nov;99(5):1211-1218. doi: 10.4269/ajtmh.18-0511.

本文引用的文献

1
Nodding syndrome may be an autoimmune reaction to the parasitic worm .点头综合征可能是对这种寄生虫的一种自身免疫反应。
Sci Transl Med. 2017 Feb 15;9(377). doi: 10.1126/scitranslmed.aaf6953.
2
The Laboratory Diagnosis of Autoimmune Encephalitis.自身免疫性脑炎的实验室诊断
J Epilepsy Res. 2016 Dec 31;6(2):45-50. doi: 10.14581/jer.16010. eCollection 2016 Dec.
3
Catatonia in Ugandan children with nodding syndrome and effects of treatment with lorazepam: a pilot study.乌干达点头综合征患儿的紧张症及劳拉西泮治疗效果:一项试点研究。
BMC Res Notes. 2015 Dec 28;8:825. doi: 10.1186/s13104-015-1805-5.
4
Nodding Syndrome May Be Only the Ears of the Hippo.点头综合征可能只是冰山一角。
PLoS Negl Trop Dis. 2015 Aug 13;9(8):e0003880. doi: 10.1371/journal.pntd.0003880. eCollection 2015 Aug.
5
'These nodding people': Experiences of having a child with nodding syndrome in postconflict Northern Uganda.“这些点头的人”:乌干达北部冲突后生育患有点头综合征孩子的经历
Epilepsy Behav. 2015 Jan;42:71-7. doi: 10.1016/j.yebeh.2014.10.027. Epub 2014 Dec 11.
6
Physical growth, puberty and hormones in adolescents with Nodding Syndrome; a pilot study.点头综合征青少年的身体生长、青春期与激素;一项试点研究。
BMC Res Notes. 2014 Nov 28;7:858. doi: 10.1186/1756-0500-7-858.
7
Patients with nodding syndrome in Uganda improve with symptomatic treatment: a cross-sectional study.乌干达点头综合征患者经对症治疗后病情改善:一项横断面研究。
BMJ Open. 2014 Nov 14;4(11):e006476. doi: 10.1136/bmjopen-2014-006476.
8
Nodding syndrome in Tanzania may not be associated with circulating anti-NMDA-and anti-VGKC receptor antibodies or decreased pyridoxal phosphate serum levels-a pilot study.坦桑尼亚的点头综合征可能与循环抗N-甲基-D-天冬氨酸受体及抗电压门控钾通道受体抗体或血清磷酸吡哆醛水平降低无关——一项初步研究。
Afr Health Sci. 2014 Jun;14(2):434-8. doi: 10.4314/ahs.v14i2.20.
9
Prevalence of nodding syndrome--Uganda, 2012-2013.点头症流行状况-乌干达,2012-2013 年。
MMWR Morb Mortal Wkly Rep. 2014 Jul 18;63(28):603-6.
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Population-level evidence for an autoimmune etiology of epilepsy.人群水平上癫痫自身免疫病因的证据。
JAMA Neurol. 2014 May;71(5):569-74. doi: 10.1001/jamaneurol.2014.188.