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[308纳米准分子激光治疗银屑病和炎症性皮肤病]

[The 308 nm Excimer laser for the treatment of psoriasis and inflammatory skin diseases].

作者信息

Fritz K, Salavastru C

机构信息

Hautärzte- und Laserzentrum Landau (Pfalz), Reduitstr. 13, 76829, Landau, Deutschland.

Medizinische und Pharmazeutische Universität Carol Davila, Bukarest, Rumänien.

出版信息

Hautarzt. 2018 Jan;69(1):35-43. doi: 10.1007/s00105-017-4105-2.

DOI:10.1007/s00105-017-4105-2
PMID:29299629
Abstract

Overall, the 308 nm Excimer laser enables not only a more effective and safer UVB therapy than classical UV phototherapy, but also targeted irradiation in higher doses with a lower cumulative load, which results in faster healing of mainly circumscribed skin changes. This also applies to therapy-resistant residual lesions which, despite systemic therapy, did not diminish. Combination therapies usually improve the result and enable the dose of UVB and systemic medication to be reduced. Excimer laser therapy can be used for an increasing number of skin diseases, especially those that respond to phototherapy or photochemotherapy.

摘要

总体而言,308纳米准分子激光不仅能提供比传统紫外线光疗更有效、更安全的中波紫外线(UVB)治疗,还能以较低的累积剂量进行高剂量的靶向照射,从而使主要为局限性的皮肤病变愈合更快。这也适用于尽管进行了全身治疗但仍未消退的治疗抵抗性残留病变。联合治疗通常能改善治疗效果,并能减少UVB和全身用药的剂量。准分子激光治疗可用于越来越多的皮肤病,尤其是那些对光疗或光化学疗法有反应的疾病。

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Treatment of oral lichen planus using 308-nm excimer laser.采用 308nm 准分子激光治疗口腔扁平苔藓。
Dermatol Ther. 2017 Sep;30(5). doi: 10.1111/dth.12510. Epub 2017 Aug 23.
2
Does imiquimod pretreatment optimize 308-nm excimer laser (UVB) therapy in psoriasis patients?咪喹莫特预处理能否优化银屑病患者的308纳米准分子激光(UVB)治疗?
Photodermatol Photoimmunol Photomed. 2017 Jul;33(4):193-202. doi: 10.1111/phpp.12299. Epub 2017 Apr 20.
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Treatment of acquired reactive perforating collagenosis with 308-nm excimer laser.用308纳米准分子激光治疗获得性反应性穿通性胶原病。
Clin Exp Dermatol. 2016 Oct;41(7):820-1. doi: 10.1111/ced.12891.
4
Use of 308 nm excimer laser for the treatment of chronic hand and foot eczema.使用308纳米准分子激光治疗慢性手足湿疹。
Int J Dermatol. 2016 Aug;55(8):e447-53. doi: 10.1111/ijd.13205. Epub 2016 Feb 24.
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Effectiveness of 308-nm Excimer Laser Therapy in Treating Alopecia Areata, Determined by Examining the Treated Sides of Selected Alopecic Patches.通过检查选定斑秃斑块的治疗部位来确定308纳米准分子激光治疗斑秃的有效性。
Dermatology. 2015;231(1):70-6. doi: 10.1159/000381912. Epub 2015 May 21.
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308nm excimer laser in dermatology.皮肤科中的308纳米准分子激光。
J Lasers Med Sci. 2014 Winter;5(1):8-12.
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Plaque-based sub-blistering dosimetry: Reaching PASI-75 after two treatments with 308-nm excimer laser in a generalized psoriasis patient.基于斑块的亚水疱剂量测定法:一名泛发性银屑病患者接受两次 308 纳米准分子激光治疗后达到 PASI-75。
J Dermatolog Treat. 2015 Feb;26(1):45-8. doi: 10.3109/09546634.2013.879094. Epub 2014 Feb 20.
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In vitro responses of neurofibroma fibroblasts, mast cells and Schwann cells obtained from patients with neurofibromatosis 1 to 308-nm excimer light and/or vitamin D3.体外实验研究 1 型神经纤维瘤病患者来源的成纤维细胞、肥大细胞和许旺细胞对 308nm 准分子光和/或维生素 D3 的反应。
J Dermatol. 2013 Sep;40(9):743-5. doi: 10.1111/1346-8138.12242. Epub 2013 Jul 16.
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Case experience of 308-nm excimer laser therapy compatibility with PUVA and oral bexarotene for the treatment of cutaneous lesions in mycosis fungoides.308纳米准分子激光疗法与补骨脂素加紫外线A及口服贝沙罗汀联合治疗蕈样肉芽肿皮肤损害的病例经验
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Case Rep Dermatol. 2012 Sep;4(3):261-4. doi: 10.1159/000345468. Epub 2012 Sep 22.