Rock M J, Reyes de la Rocha S, Lerner M, Brackett D, Wilson M F
Department of Pediatrics, University of Oklahoma Medical Center, Oklahoma City.
Anesth Analg. 1989 Apr;68(4):506-10.
The effect of aerosolized ketamine hydrochloride was investigated by measuring airway resistance with a two-compartment plethysmograph in guinea pigs challenged with histamine. In the first phase of the study, treatment with ketamine prior to histamine challenge did not protect against elevation of airway resistance. In the second phase of the study, ketamine inhalation after histamine challenge did not significantly diminish airway resistance. Aerosolized ketamine is not recommended for use in human subjects with asthma.
通过使用双室体积描记器测量组胺激发的豚鼠气道阻力，研究了雾化盐酸氯胺酮的效果。在研究的第一阶段，组胺激发前给予氯胺酮治疗并不能预防气道阻力升高。在研究的第二阶段，组胺激发后吸入氯胺酮并没有显著降低气道阻力。不建议雾化氯胺酮用于哮喘患者。
