二芳基[d,f][1,3]二氮杂䓬类化合物的合成及构效关系研究 作为潜在的抗癌剂。
Synthesis and structure-activity relationship study of diaryl[d,f][1,3]diazepines as potential anti-cancer agents.
机构信息
The Center for Combinatorial Chemistry and Drug Discovery, The College of Chemistry and The School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130012, Jilin, People's Republic of China.
出版信息
Mol Divers. 2018 May;22(2):323-333. doi: 10.1007/s11030-017-9805-0. Epub 2018 Jan 3.
We herein report the synthesis, biological activity and preliminary structure-activity relationships of a series of diaryl[1,3]diazepines. These compounds were able to inhibit the proliferation of many cancer cell lines, such as HeLa, MCF-7, SGC7901 and A549. When HeLa cells were treated with lead compounds 7j and 7k at 3 [Formula: see text] concentration, cell arrest was observed in the G2/M phase.
我们在此报告了一系列二芳基[1,3]二氮杂环庚烷的合成、生物活性和初步的构效关系。这些化合物能够抑制许多癌细胞系的增殖，如 HeLa、MCF-7、SGC7901 和 A549。当 HeLa 细胞用化合物 7j 和 7k 在 3 [Formula: see text]浓度处理时，观察到细胞在 G2/M 期停滞。
Zotero 插件