Rashid Muhammad A, Ashraf Aisha, Rehman Sahibzada S, Shahid Shaukat A, Mahmood Adeel, Faruq Muhammad
Department of Chemistry, Government Postgraduate College of Science, Faisalabad, Pakistan.
Department of Chemistry, Government College Women University, Faisalabad, Pakistan.
Curr Org Synth. 2019;16(5):709-729. doi: 10.2174/1570179416666190703113807.
1,4-Diazepines are two nitrogen containing seven membered heterocyclic compounds and associated with a wide range of biological activities. Due to its medicinal importance, scientists are actively involved in the synthesis, reactions and biological evaluation of 1,4-diazepines since number of decades.
The primary purpose of this review is to discuss the synthetic schemes and reactivity of 1,4- diazepines. This article also describes biological aspects of 1,4-diazepine derivatives, that can be usefully exploited for the pharmaceutical sector.
This review summarizes the abundant literature on synthetic routes, chemical reactions and biological attributes of 1,4-diazepine derivatives. We concluded that 1,4-diazepines have significant importance due to their biological activities like antipsychotic, anxiolytic, anthelmintic, anticonvulsant, antibacterial, antifungal and anticancer. 1,4-diazepine derivatives with significant biological activities could be explored for potential use in the pharmaceutical industries.
1,4-二氮杂卓是含两个氮原子的七元杂环化合物，具有广泛的生物活性。由于其药用价值，几十年来科学家们一直积极参与1,4-二氮杂卓的合成、反应及生物学评价。
本综述的主要目的是讨论1,4-二氮杂卓的合成方案及反应活性。本文还描述了1,4-二氮杂卓衍生物的生物学特性，这些特性可有效地应用于制药领域。
本综述总结了关于1,4-二氮杂卓衍生物合成路线、化学反应及生物学特性的大量文献。我们得出结论，1,4-二氮杂卓因其抗精神病、抗焦虑、驱虫、抗惊厥、抗菌、抗真菌及抗癌等生物活性而具有重要意义。具有显著生物活性的1,4-二氮杂卓衍生物有望用于制药工业。
