过敏性休克时的心肌底物利用情况。

Myocardial substrate utilization in anaphylactic shock.

作者信息

Spitzer J J

出版信息

Proc Soc Exp Biol Med. 1976 Jan;151(1):28-31. doi: 10.3181/00379727-151-39136.

Abstract

Changes in myocardial substrate utilization were studied in anesthetized dogs following the production of anaphylactic shock. Mean arterial blood pressure, cardiac output, and pH decreased significantly during this form of shock. Myocardial FFA oxidation was greatly diminished especially within the first hour following challenge and lactate uptake more than doubled during the same time. Thus, it is concluded that myocardial substrate utilization shifted away from FFA and towards lactate during anaphylactic shock and these changes resembled those observed following an acute, severe hemorrhage, or the administration of E. coli endotoxin.

摘要

在麻醉犬身上研究了过敏性休克发生后心肌底物利用的变化。在这种休克形式下，平均动脉血压、心输出量和pH值显著下降。心肌游离脂肪酸（FFA）氧化大幅减少，尤其是在激发后的第一小时内，而同期乳酸摄取增加了一倍多。因此，得出结论，在过敏性休克期间，心肌底物利用从FFA转向乳酸，这些变化类似于急性严重出血或给予大肠杆菌内毒素后观察到的变化。