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尼日利亚的高阶多胞胎生育情况:一家私立医疗机构的经验、挑战及新生儿结局

Higher order multiple births in Nigeria: Experiences, challenges and neonatal outcomes in a private health facility.

作者信息

Ezenwa B, Oseni O, Akintan P, Aligwekwe P, Chukwukelu B, Fashola O, Ogunmokun A, Odukoya O

机构信息

Department of Paediatrics, The Eko Hospital, Ikeja, Nigeria.

Department of Paediatrics, LUTH, Lagos, Nigeria.

出版信息

Niger J Clin Pract. 2017 Nov;20(11):1439-1443. doi: 10.4103/njcp.njcp_71_17.

Abstract

OBJECTIVES

The aim of this study is to describe the experience and outcome of higher order multiple (HOM) births in a private tertiary health facility in Nigeria.

MATERIALS AND METHODS

This was a retrospective review of records of HOM over 3 years in a private tertiary health facility in Nigeria. Relevant data on HOM births were extracted from both the patients' case notes, admission registers and maternity ward and delivery records of the hospital using a predesigned pro forma. Data were analyzed using Statistical Package for Social Sciences Version 22.0.

RESULTS

The prevalence of HOM births was 0.72% of 1950 births over the 3 years study period; while for triplets, quadruplets, and quintuplets were 0.56%, 0.1% and 0.05%, respectively. The mean gestational age was 32 ± 3 weeks, and all except three sets of triplets were by Assisted Reproductive Technology (ART). Respiratory distress syndrome, neonatal jaundice, and neonatal sepsis accounted for more than 80% of the neonatal complications noted in HOM births. However, there was no significant difference between neonatal survival of HOM as compared to twin deliveries, P = 0.08.

CONCLUSION

HOM is becoming increasingly common in Nigeria. The strongest risk factor is ART, and neonatal complications are common reinforcing the need to streamline ART protocols in Nigeria.

摘要

目的

本研究旨在描述尼日利亚一家私立三级医疗机构中高阶多胞胎(HOM)分娩的经验和结果。

材料与方法

这是对尼日利亚一家私立三级医疗机构3年期间高阶多胞胎记录的回顾性研究。使用预先设计的表格从患者病历、入院登记册以及医院产科病房和分娩记录中提取高阶多胞胎分娩的相关数据。数据采用社会科学统计软件包第22.0版进行分析。

结果

在3年的研究期间,高阶多胞胎分娩的发生率占1950例分娩的0.72%;三胞胎、四胞胎和五胞胎的发生率分别为0.56%、0.1%和0.05%。平均孕周为32±3周,除三组三胞胎外,其余均通过辅助生殖技术(ART)受孕。呼吸窘迫综合征、新生儿黄疸和新生儿败血症占高阶多胞胎分娩中所记录新生儿并发症的80%以上。然而,与双胎分娩相比,高阶多胞胎的新生儿存活率无显著差异,P = 0.08。

结论

在尼日利亚,高阶多胞胎越来越常见。最强的风险因素是辅助生殖技术,且新生儿并发症很常见,这进一步凸显了在尼日利亚简化辅助生殖技术方案的必要性。

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