铂（IV）前药共轭超分子六边形的配位驱动自组装

Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon.

作者信息

Yue Zhizhou, Wang Han, Li Yiming, Qin Yi, Xu Lin, Bowers David J, Gangoda Mahinda, Li Xiaopeng, Yang Hai-Bo, Zheng Yao-Rong

机构信息

Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA.

出版信息

Chem Commun (Camb). 2018 Jan 18;54(7):731-734. doi: 10.1039/c7cc07622c.

DOI:10.1039/c7cc07622c

PMID:29303526

Abstract

This article presents a new strategy to engage coordination-driven self-assembly for platinum drug delivery. The self-assembled supramolecular hexagon is conjugated with three equivalents of Pt(iv) prodrugs and displays a superior therapeutic index compared to cisplatin against a panel of human cancer cell lines.

摘要

本文提出了一种用于铂类药物递送的配位驱动自组装新策略。自组装超分子六边形与三当量的铂（IV）前药共轭，与顺铂相比，对一组人类癌细胞系显示出更高的治疗指数。