文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

一氧化氮释放的铂（IV）前药能有效抑制癌细胞的增殖和转移。

Nitric oxide-releasing platinum(IV) prodrug efficiently inhibits proliferation and metastasis of cancer cells.

机构信息

CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Department of Pharmacy, University of Science and Technology of China, Hefei, Anhui 230001, China.

出版信息

Chem Commun (Camb). 2020 Nov 12;56(90):14051-14054. doi: 10.1039/d0cc05422d.

DOI:10.1039/d0cc05422d
PMID:33103676
Abstract

A dual-functional Pt(iv) prodrug, Pt-furoxan, can release cytotoxic cisplatin and signaling molecule NO upon cellular internalization. NO modulates the cellular response towards cisplatin, leading to a synergistic anti-proliferation effect and a promising anti-metastasis effect both in vitro and in vivo.

摘要

一种双功能的 Pt(iv) 前药，Pt-呋喃丹，在细胞内化后可以释放细胞毒性顺铂和顺铂信号分子 NO。NO 调节细胞对顺铂的反应，导致协同的抗增殖作用和有前途的抗转移作用，无论是在体外还是体内。

相似文献

[1]
Nitric oxide-releasing platinum(IV) prodrug efficiently inhibits proliferation and metastasis of cancer cells.

Chem Commun (Camb). 2020-11-12

[2]
Complexes of oxoplatin with rhein and ferulic acid ligands as platinum(iv) prodrugs with high anti-tumor activity.

Dalton Trans. 2020-1-16

[3]
Coordination-driven self-assembly of a Pt(iv) prodrug-conjugated supramolecular hexagon.

Chem Commun (Camb). 2018-1-18

[4]
A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.

Chem Commun (Camb). 2012-11-11

[5]
Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo.

Eur J Med Chem. 2018-8-27

[6]
A cancer specific oxaliplatin-releasing Pt(iv)-prodrug.

Dalton Trans. 2018-5-15

[7]
Are Pt(IV) Prodrugs That Release Combretastatin A4 True Multi-action Prodrugs?

J Med Chem. 2021-8-12

[8]
Monochalcoplatin: An Actively Transported, Quickly Reducible, and Highly Potent Pt Anticancer Prodrug.

Angew Chem Int Ed Engl. 2018-6-14

[9]
Alternative mechanism of action of the DNP Pt prodrug: intracellular cisplatin release and the mitochondria-mediated apoptotic pathway.

Dalton Trans. 2021-6-15

[10]
A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant Pt Prodrug Activation.

Angew Chem Int Ed Engl. 2019-8-30

引用本文的文献

[1]
Metal-phenolic nanozyme as a ferroptosis inhibitor for alleviating cisplatin-induced acute kidney injury.

Front Pharmacol. 2025-4-1

[2]
G-quadruplex-guided cisplatin triggers multiple pathways in targeted chemotherapy and immunotherapy.

Chem Sci. 2024-5-15

[3]
High-fat stimulation induces atrial neural remodeling by reducing NO production via the CRIF1/eNOS/P21 axi.

Lipids Health Dis. 2023-11-6

[4]
Anticancer Activity and Mode of Action of Cu(II), Zn(II), and Mn(II) Complexes with 5-Chloro-2--(2-quinolylmethylene)aminophenol.

Molecules. 2023-6-20

[5]
Cytotoxicity towards Breast Cancer Cells of Pluronic F-127/Hyaluronic Acid Hydrogel Containing Nitric Oxide Donor and Silica Nanoparticles Loaded with Cisplatin.

Pharmaceutics. 2022-12-17

[6]
Biomineralized hybrid nanodots for tumor therapy NIR-II fluorescence and photothermal imaging.

Front Bioeng Biotechnol. 2022-10-31

[7]
Delivery of Nitric Oxide in the Cardiovascular System: Implications for Clinical Diagnosis and Therapy.

Int J Mol Sci. 2021-11-10

[8]
Recent Advances in the Synthesis and Biomedical Applications of Heterocyclic NO-Donors.

Molecules. 2021-9-21

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索