一氧化氮释放的铂（IV）前药能有效抑制癌细胞的增殖和转移。
Nitric oxide-releasing platinum(IV) prodrug efficiently inhibits proliferation and metastasis of cancer cells.
机构信息
CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, Department of Pharmacy, University of Science and Technology of China, Hefei, Anhui 230001, China.
出版信息
Chem Commun (Camb). 2020 Nov 12;56(90):14051-14054. doi: 10.1039/d0cc05422d.
A dual-functional Pt(iv) prodrug, Pt-furoxan, can release cytotoxic cisplatin and signaling molecule NO upon cellular internalization. NO modulates the cellular response towards cisplatin, leading to a synergistic anti-proliferation effect and a promising anti-metastasis effect both in vitro and in vivo.
一种双功能的 Pt(iv) 前药，Pt-呋喃丹，在细胞内化后可以释放细胞毒性顺铂和顺铂信号分子 NO。NO 调节细胞对顺铂的反应，导致协同的抗增殖作用和有前途的抗转移作用，无论是在体外还是体内。
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