Salter-Cid L, Bigger C H
Biol Bull. 1991 Aug;181(1):127-134. doi: 10.2307/1542495.
This study of histocompatibility demonstrates that the gorgonian Swiftia exserta (Coelenterata, Anthozoan) fulfills the minimal functional criteria of cytotoxicity, specificity, and altered secondary response (memory) that characterize an adaptive immune response. All autografts (self grafts) fused, and all allografts (intraspecific grafts) underwent rejection, which is characterized by rapid and progressive blanching, necrosis, and loss of tissue in the immediate contact area. Initial reactions required 7-9 days to produce 1 mm of necrosis, but after a resting period, a second contact at a new tissue area yielded the same reaction in 3-4 days. After primary sensitization, intervals of up to eight weeks still produced a significantly accelerated secondary response. Significant differences between the reaction times of second set and third party allografts demonstrated recognition specificity in these responses. Thus, this is the first report of an adaptive alloimmune response in gorgonians.
这项组织相容性研究表明，柳珊瑚Swiftia exserta（腔肠动物，珊瑚虫纲）满足细胞毒性、特异性以及二次反应改变（记忆）这些构成适应性免疫反应的最低功能标准。所有自体移植（自身移植）均融合，而所有同种异体移植（种内移植）均发生排斥反应，其特征为在直接接触区域迅速且渐进性地变白、坏死以及组织丧失。初始反应需要7 - 9天产生1毫米的坏死，但在一段静止期后，在新的组织区域再次接触会在3 - 4天内产生相同反应。初次致敏后，长达八周的间隔仍会产生显著加速的二次反应。第二组和第三方同种异体移植反应时间的显著差异表明这些反应具有识别特异性。因此，这是关于柳珊瑚适应性同种异体免疫反应的首次报告。
