临床单侧假性剥脱综合征与年龄相关性黄斑变性之间关系的评估
An Evaluation of the Relationship Between Clinically Unilateral Pseudoexfoliation Syndrome and Age-Related Macular Degeneration.
作者信息
Zengin Mehmet Ozgur, Karti Omer, Karahan Eyyup, Kusbeci Tuncay
出版信息
Ophthalmic Surg Lasers Imaging Retina. 2018 Jan 1;49(1):12-19. doi: 10.3928/23258160-20171215-02.
BACKGROUND AND OBJECTIVE
To evaluate the relationship between age-related macular degeneration (AMD) and clinically unilateral pseudoexfoliation syndrome (XFS).
PATIENTS AND METHODS
Seventy-six patients (152 eyes) with bilateral AMD and clinically unilateral XFS were included. Eyes with AMD were divided into three stages (early, intermediate, and late), based on the Beckman Initiative for Macular Research Classification Committee of fundus findings. The distribution of AMD lesions was assessed in both groups, and the subfoveal choroidal thickness (SFCT) was measured using enhanced depth imaging spectral-domain optical coherence tomography (SD-OCT).
RESULTS
There were significantly more early and intermediate-stage AMD cases in eyes with XFS than in non-XFS fellow eyes (P < .05). In contrast, there were significantly fewer wet AMD cases in XFS eyes than in non-XFS fellow eyes (P < .05). SFCT in all AMD stages was significantly lower in eyes with XFS (P < .05).
CONCLUSION
XFS was associated with a lower prevalence of wet AMD. Further studies are required to elucidate this association. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:12-19.].
背景与目的
评估年龄相关性黄斑变性（AMD）与临床单侧假性剥脱综合征（XFS）之间的关系。
患者与方法
纳入76例（152只眼）患有双侧AMD且临床单侧XFS的患者。根据黄斑研究贝克曼倡议分类委员会的眼底检查结果，将患有AMD的眼分为三个阶段（早期、中期和晚期）。评估两组中AMD病变的分布情况，并使用增强深度成像光谱域光学相干断层扫描（SD-OCT）测量黄斑下脉络膜厚度（SFCT）。
结果
与非XFS对侧眼相比，XFS眼中早期和中期AMD病例明显更多（P < 0.05）。相反，XFS眼中湿性AMD病例明显少于非XFS对侧眼（P < 0.05）。XFS眼中所有AMD阶段的SFCT均显著更低（P < 0.05）。
结论
XFS与湿性AMD的患病率较低相关。需要进一步研究以阐明这种关联。[《眼科手术、激光与视网膜成像》。2018年；49:12 - 19。]
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