乙醇脱氢酶缺陷型鹿鼠体内丁醇代谢的特征
Characteristics of butanol metabolism in alcohol dehydrogenase-deficient deermice.
作者信息
Alderman J A, Kato S, Lieber C S
机构信息
Alcohol Research and Treatment Center, Bronx VA Medical Center, NY.
出版信息
Biochem J. 1989 Jan 15;257(2):615-7. doi: 10.1042/bj2570615.
Abstract
Deermice lacking the low-Km alcohol dehydrogenase eliminated butan-1-ol, a substrate for microsomal oxidation but not for catalase, at 117 mumol/min per kg body wt. Microsomal fractions and hepatocytes metabolized butan-1-ol also (Vmax. = 6.7 nmol/min per nmol of cytochrome P-450, Km = 0.85 mM; Vmax. = 5.3 nmol/min per 10(6) cells, Km = 0.71 mM respectively). These results are consistent with alcohol oxidation by the microsomal system in these deermice.
摘要
缺乏低 Km 乙醇脱氢酶的鹿鼠以每千克体重 117 μmol/分钟的速度消除丁醇，丁醇是微粒体氧化的底物而非过氧化氢酶的底物。微粒体组分和肝细胞也代谢丁醇（最大反应速度分别为每 nmol 细胞色素 P - 450 6.7 nmol/分钟，米氏常数 Km = 0.85 mM；每 10⁶ 个细胞 5.3 nmol/分钟，Km = 0.71 mM）。这些结果与这些鹿鼠中微粒体系统进行的乙醇氧化一致。
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本文引用的文献
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Ethanol metabolism in Peromyscus genetically deficient in alcohol dehydrogenase.
Biochem Pharmacol. 1980 Feb;29(2):125-30. doi: 10.1016/0006-2952(80)90318-4.
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Ethanol metabolism in vivo by the microsomal ethanol-oxidizing system in deermice lacking alcohol dehydrogenase (ADH).在缺乏乙醇脱氢酶（ADH）的鹿鼠体内，微粒体乙醇氧化系统对乙醇的代谢作用。
Biochem Pharmacol. 1984 Mar 1;33(5):807-14. doi: 10.1016/0006-2952(84)90466-0.
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Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo.肝微粒体乙醇氧化系统。体外特性及体内适应性
J Biol Chem. 1970 May 25;245(10):2505-12.
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NADPH-dependent oxidation of methanol, ethanol, propanol and butanol by hepatic microsomes.肝微粒体对甲醇、乙醇、丙醇和丁醇的NADPH依赖性氧化作用。
Biochem Biophys Res Commun. 1974 Sep 23;60(2):851-7. doi: 10.1016/0006-291x(74)90319-2.
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Catalase-dependent ethanol metabolism in vivo in deermice lacking alcohol dehydrogenase.缺乏乙醇脱氢酶的鹿鼠体内过氧化氢酶依赖性乙醇代谢
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Assessment of the role of non-ADH ethanol oxidation in vivo and in hepatocytes from deermice.评估非乙醇脱氢酶（ADH）乙醇氧化在体内及鹿鼠肝细胞中的作用。
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