大鼠唾液腺中β-肾上腺素能诱导半胱氨酸蛋白酶抑制剂mRNA的产生。
Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands.
作者信息
Shaw P A, Barka T
机构信息
Department of Anatomy, Mount Sinai School of Medicine, New York, NY 10029.
出版信息
Biochem J. 1989 Feb 1;257(3):685-9. doi: 10.1042/bj2570685.
Abstract
Transcripts encoding the cysteine-proteinase inhibitor rat cystatin S are induced in submandibular and parotid glands by the beta-adrenergic agonist isoproterenol (isoprenaline). High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Post-transcriptionally the size of the mRNA decreases, owing to a shortening of the poly(A) tail.
摘要
编码半胱氨酸蛋白酶抑制剂大鼠胱抑素S的转录本，在颌下腺和腮腺中被β-肾上腺素能激动剂异丙肾上腺素（喘息定）诱导产生。在停用儿茶酚胺后，慢性处理动物的腺体中高水平的胱抑素S mRNA持续存在6天，这表明该mRNA具有较长的半衰期。转录后，由于多聚腺苷酸尾的缩短，mRNA的大小减小。
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本文引用的文献
1
INDUCED CELL PROLIFERATION: THE EFFECT OF ISOPROTERENOL.
Exp Cell Res. 1965 Mar;37:662-79. doi: 10.1016/0014-4827(65)90214-4.
2
Accelerated development of salivary glands of early postnatal rats following isoproterenol.
Proc Soc Exp Biol Med. 1963 Feb;112:320-4. doi: 10.3181/00379727-112-28029.
3
Studies on LM protein appearing in submandibular glands of isoproterenol-treated rats. II. Physicochemical properties.
Chem Pharm Bull (Tokyo). 1981 May;29(5):1373-6. doi: 10.1248/cpb.29.1373.
4
Studies on LM protein appearing in submandibular glands of isoproterenol-treated rats. I. Purification and characteristics of its appearance.
Chem Pharm Bull (Tokyo). 1981 May;29(5):1365-72. doi: 10.1248/cpb.29.1365.
5
Studies on LM protein appearing in submandibular glands of isoproterenol-treated rats. IV. Size and shape determination.
Chem Pharm Bull (Tokyo). 1982 Mar;30(3):1063-5. doi: 10.1248/cpb.30.1063.
6
Nucleotide sequence analysis of a proline-rich protein cDNA and peptide homologies of rat and human proline-rich proteins.
J Biol Chem. 1984 Aug 25;259(16):10475-80.
7
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.
Anal Biochem. 1984 Feb;137(1):266-7. doi: 10.1016/0003-2697(84)90381-6.
8
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
Anal Biochem. 1983 Jul 1;132(1):6-13. doi: 10.1016/0003-2697(83)90418-9.
9
10
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5. doi: 10.1073/pnas.77.9.5201.
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