大鼠唾液腺中β-肾上腺素能诱导半胱氨酸蛋白酶抑制剂mRNA的产生。
Beta-adrenergic induction of a cysteine-proteinase-inhibitor mRNA in rat salivary glands.
作者信息
Shaw P A, Barka T
机构信息
Department of Anatomy, Mount Sinai School of Medicine, New York, NY 10029.
出版信息
Biochem J. 1989 Feb 1;257(3):685-9. doi: 10.1042/bj2570685.
Abstract
Transcripts encoding the cysteine-proteinase inhibitor rat cystatin S are induced in submandibular and parotid glands by the beta-adrenergic agonist isoproterenol (isoprenaline). High levels of cystatin S mRNA persist in glands of chronically treated animals for 6 days after discontinuation of the catecholamine, indicating a long half-life of the mRNA. Post-transcriptionally the size of the mRNA decreases, owing to a shortening of the poly(A) tail.
摘要
编码半胱氨酸蛋白酶抑制剂大鼠胱抑素S的转录本，在颌下腺和腮腺中被β-肾上腺素能激动剂异丙肾上腺素（喘息定）诱导产生。在停用儿茶酚胺后，慢性处理动物的腺体中高水平的胱抑素S mRNA持续存在6天，这表明该mRNA具有较长的半衰期。转录后，由于多聚腺苷酸尾的缩短，mRNA的大小减小。
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