雌二醇通过激活 ERα 和 ERβ 增强雌性小鼠对乙醇的奖赏。
Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ.
机构信息
Graduate Program in Neuroscience, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, United States; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, United States.
Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, 1601 West Taylor Street, MC 912, Chicago, IL 60612, United States.
出版信息
Horm Behav. 2018 Feb;98:159-164. doi: 10.1016/j.yhbeh.2018.01.001. Epub 2018 Feb 9.
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERα and ERβ, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test. E2 enhanced ethanol CPP and, while specific activation of either receptor alone had no effect, co-activation of ERα and ERβ also enhanced ethanol CPP, suggesting that E2 enhances ethanol reward in female mice through actions at both ERα and ERβ. These results have implications for sex differences in the development of AUD, suggesting that women may find ethanol more rewarding than men because of higher circulating E2 levels.
酒精使用障碍（AUD）在男性和女性中的表现不同，但对于大脑对乙醇反应的性别差异知之甚少。已知甾体激素 17β-雌二醇（E2）调节雌性啮齿动物的自愿性乙醇摄入。然而，E2 作为乙醇奖赏的调节剂的作用尚未被研究。在这项研究中，我们使用条件性位置偏好（CPP）测试测试了 E2 和选择性经典雌激素受体 ERα 和 ERβ 的激动剂对去卵巢（OVX）小鼠乙醇奖赏的影响。E2 增强了乙醇 CPP，而单独激活任一受体都没有影响，ERα 和 ERβ 的共同激活也增强了乙醇 CPP，这表明 E2 通过作用于 ERα 和 ERβ 增强了雌性小鼠对乙醇的奖赏。这些结果对 AUD 的性别差异有影响，这表明女性可能会发现乙醇比男性更有吸引力，因为女性的循环 E2 水平更高。
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