Department of Medicine, Division of Hematology and Oncology, Thrombosis and Hemostasis Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, Tromsø, Norway.
Department of Medicine, Division of Hematology and Oncology, Thrombosis and Hemostasis Program, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Thromb Res. 2018 Apr;164 Suppl 1(Suppl 1):S48-S53. doi: 10.1016/j.thromres.2017.12.018. Epub 2017 Dec 29.
Cancer patients have an increased risk of venous thromboembolism (VTE) compared with the general population. Mouse models are used to better understand the mechanisms of cancer-associated thrombosis. Several mouse models of cancer-associated thrombosis have been developed that use different mouse strains, tumors, tumor sites and thrombosis models. In this review, we summarize these different models. These models have been used to determine the role of different pathways in cancer-associated thrombosis. For instance, they have revealed roles for tumor-derived tissue factor-positive microvesicles and neutrophil extracellular traps in thrombosis in tumor-bearing mice. A better understanding of the mechanisms of cancer-associated thrombosis may allow the development of new therapies to reduce thrombosis in cancer patients.
癌症患者发生静脉血栓栓塞症（venous thromboembolism，VTE）的风险高于普通人群。人们使用小鼠模型来更好地理解与癌症相关的血栓形成机制。目前已经开发出多种与癌症相关的血栓形成小鼠模型，这些模型使用了不同的小鼠品系、肿瘤、肿瘤部位和血栓形成模型。在这篇综述中，我们对这些不同的模型进行了总结。这些模型被用于确定不同通路在与癌症相关的血栓形成中的作用。例如，它们揭示了肿瘤来源的组织因子阳性微囊泡和中性粒细胞胞外诱捕网在荷瘤小鼠血栓形成中的作用。更好地理解与癌症相关的血栓形成机制可能会促进开发新的治疗方法，以减少癌症患者的血栓形成。
