Fellmeth Gracia, Plugge Emma H, Carrara Verena, Fazel Mina, Oo May May, Phichitphadungtham Yuwapha, Pimanpanarak Mupawjay, Wai Naw Kerry, Mu Oh, Charunwatthana Prakaykaew, Nosten François, Fitzpatrick Raymond, Mcgready Rose
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Faculty of Tropical Medicine, Mahidol University, Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mae Sot, Thailand.
BMJ Open. 2018 Jan 5;8(1):e017129. doi: 10.1136/bmjopen-2017-017129.
Perinatal depression is a significant contributor to maternal morbidity. Migrant women in resource-poor settings may be at increased risk, yet little research has been conducted in low-income and middle-income settings. This prospective cohort study of migrant women on the Thai-Myanmar border aims to establish prevalence of perinatal depression, identify risk factors for perinatal depression and examine associations with infant outcomes.
Participating women are labour migrants and refugees living on the Thai-Myanmar border. A total of 568 women were recruited in their first trimester of pregnancy and are being followed up to 1-year postpartum.
At baseline, women in our study had a median age of 25 years, the predominant ethnicity was Sgaw Karen (48.9%), agriculture was the main employment sector (39.2%) and educational attainment was low with a median of 4 years of education. In the first trimester of pregnancy, a quarter (25.8%; 95% CI 22.3 to 29.5) of all women were depressed as diagnosed by the .
Follow-up is ongoing and expected to continue until January 2018. The prevalence of depression at later stages of pregnancy and during the first postpartum year will be identified, and associations between depression status and demographic, social, migration-related, medical, obstetric and infant factors will be quantified.
NCT02790905.
围产期抑郁症是导致孕产妇发病的一个重要因素。生活在资源匮乏地区的流动妇女可能面临更高的风险，但在低收入和中等收入地区对此开展的研究很少。这项针对泰缅边境流动妇女的前瞻性队列研究旨在确定围产期抑郁症的患病率，识别围产期抑郁症的风险因素，并研究其与婴儿结局的关联。
参与研究的妇女为生活在泰缅边境的劳务移民和难民。共有568名妇女在怀孕早期被招募，并将接受为期1年的产后随访。
在基线时，我们研究中的妇女中位年龄为25岁，主要种族为克伦族（48.9%），主要就业部门为农业（39.2%），教育程度较低，中位受教育年限为4年。在怀孕早期，所有妇女中有四分之一（25.8%；95%置信区间22.3至29.5）被诊断为抑郁。
随访正在进行，预计将持续到2018年1月。将确定怀孕后期和产后第一年抑郁症的患病率，并对抑郁状态与人口统计学、社会、移民相关、医学、产科和婴儿因素之间的关联进行量化。
NCT02790905。
