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荷兰阿姆斯特丹地区由助产士主导护理与由产科医生主导护理的低风险女性的产时及新生儿死亡率:一项倾向得分匹配研究

Intrapartum and neonatal mortality among low-risk women in midwife-led versus obstetrician-led care in the Amsterdam region of the Netherlands: a propensity score matched study.

作者信息

Wiegerinck Melanie M J, van der Goes Birgit Y, Ravelli Anita C J, van der Post Joris A M, Buist Fayette C D, Tamminga Pieter, Mol Ben W

机构信息

Department of Obstetrics and Gynaecology, Academic Medical Center, Amsterdam, The Netherlands.

Department of Obstetrics and Gynaecology, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

BMJ Open. 2018 Jan 5;8(1):e018845. doi: 10.1136/bmjopen-2017-018845.

Abstract

OBJECTIVE

To compare intrapartum and neonatal mortality in low-risk term women starting labour in midwife-led versus obstetrician-led care.

STUDY DESIGN

We performed a propensity score matched study using data from our national perinatal register, completed with data from medical files. We studied women without major risk factors with singleton pregnancies who gave birth at term between 2005 and 2008 in the Amsterdam region of the Netherlands. Major risk factors comprised non-vertex position of the fetus, previous Caesarean birth, hypertension, (gestational) diabetes mellitus, post-term pregnancy (≥42 weeks), prolonged rupture of membranes (>24 hours), vaginal bleeding in the second half of pregnancy or induced labour. Groups were devided by midwife-led versus obstetrician-led care at the onset of labour. The primary outcome was intrapartum and neonatal (<28 days) mortality. Secondary outcomes included obstetric interventions, 5 min Apgar scores<7 and neonatal intensive care admittance for >24 hours.

RESULTS

We studied 57 396 women. Perinatal mortality occurred in 30 of 46 764 (0.64‰) women in midwife-led care and in 2 of 10 632 (0.19‰) women in obstetrician-led care (OR 3.4, 95% CI 0.82 to 14.3). A propensity score matched analysis in a 1:1 ratio with 10 632 women per group revealed an OR for perinatal mortality of 4.0 (95% CI 0.85 to 18.9).

CONCLUSION

Among low-risk women, midwife-led care at the onset of labour was associated with a statistically non-significant higher mortality rate.

摘要

目的

比较在助产士主导护理与产科医生主导护理下开始分娩的低风险足月孕妇的产时及新生儿死亡率。

研究设计

我们使用国家围产期登记数据并结合病历数据进行了一项倾向评分匹配研究。我们研究了2005年至2008年在荷兰阿姆斯特丹地区分娩的单胎妊娠且无主要风险因素的妇女。主要风险因素包括胎儿非头位、既往剖宫产史、高血压、(妊娠)糖尿病、过期妊娠(≥42周)、胎膜早破时间延长(>24小时)、妊娠后半期阴道出血或引产。根据分娩开始时是助产士主导护理还是产科医生主导护理将研究对象分组。主要结局是产时及新生儿(<28天)死亡率。次要结局包括产科干预、5分钟阿氏评分<7分以及新生儿重症监护入院时间>24小时。

结果

我们研究了57396名妇女。在助产士主导护理的46764名妇女中有30名(0.64‰)发生围产期死亡,在产科医生主导护理的10632名妇女中有2名(0.19‰)发生围产期死亡(比值比3.4,95%置信区间0.82至14.3)。按1:1比例进行倾向评分匹配分析,每组10632名妇女,结果显示围产期死亡的比值比为4.0(95%置信区间0.85至18.9)。

结论

在低风险妇女中,分娩开始时由助产士主导的护理与统计学上无显著差异的较高死亡率相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cef/5781008/32a08584bf4e/bmjopen-2017-018845f01.jpg

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